Uptake of cadmium from Pacific oysters (Crassostrea gigas) in British Columbia oyster growers
Uptake of cadmium from Pacific oysters (Crassostrea gigas) in British Columbia oyster growers
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DOI：
10.1016/j.envres.2008.01.014
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发表时间：
2008-06-01
影响因子：
8.3
通讯作者：
Teschke, Kay
中科院分区：
文献类型：
--
作者：
Copes, Ray;Clark, Nina Annika;Teschke, Kay
背景：与大西洋牡蛎相比，从华盛顿到阿拉斯加的北美沿岸的太平洋牡蛎含有的镉（Cd）浓度很高，经常超过2 μ g/g湿重，但目前尚不清楚消费者是否吸收了这些Cd。目的：探讨食用牡蛎对高食用量人群血液和尿液中镉含量的影响。方法：对61名平均年龄为47.3 +/- 7.6岁（33-64岁）的非吸烟牡蛎养殖者及其家庭成员进行电话访谈，评估他们目前和开始养殖牡蛎前5年的牡蛎消费量和其他Cd暴露来源。测定血、尿镉浓度。结果：血Cd几何平均浓度为0.83 μ g/L，尿Cd几何平均浓度为0.76 μ g/g肌酐。36%的参与者尿Cd水平高于1 μ g/g肌酐，5%高于2 μ g/g肌酐。最近（过去12个月）和长期食用牡蛎是血Cd的积极预测因子，但不能直接预测尿Cd。预测血Cd变化的最佳模型包括最近摄入牡蛎来源的Cd、血清铁浓度和最近食用番茄酱（R-2 = 0.34, p = 0.00004），后两个变量显示出保护作用。预测尿Cd的因素是血Cd浓度和牡蛎养殖时间。在饲养牡蛎12年后，血液中镉的含量出现上升，这可能是由于在此期间食用了更多的牡蛎。结论：牡蛎来源的镉具有生物可利用性，并影响体内镉的储存。(C) 2008爱思唯尔公司版权所有。
Background: Pacific oysters along the North American coast from Washington to Alaska contain concentrations of cadmium (Cd) that are high by comparison with Atlantic oysters, frequently exceeding 2 mu g/g wet weight, but it is unclear whether this Cd is absorbed by consumers. Objectives: To determine the effect of oyster consumption on Cd in blood and urine among a group with high oyster consumption.Methods: Sixty-one non-smoking oyster growers and family members with a mean age of 47.3 +/- 7.6 years (range 33-64) were interviewed by telephone to assess their oyster consumption and other sources of Cd exposure at present and 5 years prior to the start of oyster farming. Their blood and urine Cd concentrations were measured.Results: The geometric mean Cd concentration in blood was 0.83 mu g/L and in urine was 0.76 mu g/g creatinine. Thirty-six percent of participants had urinary Cd levels above 1 mu g/g creatinine and 5% were above 2 mu g/g creatinine. Recent (last 12 months) and long-term oyster consumptions were positive predictors of blood Cd but did not directly predict urinary Cd. The optimal model for predicting the variance in blood Cd included recent intake of oyster-derived Cd, serum iron concentration and recent ketchup consumption (R-2 = 0.34, p = 0.00004), with the latter two variables showing a protective effect. The factors found to predict urinary Cd were blood Cd concentration and duration of oyster farming. A rise in blood Cd was observed after 12 years of farming oysters, likely caused by higher consumption of oysters during this period.Conclusions: Oyster-derived Cd is bioavailable and affects body stores of the metal. (C) 2008 Elsevier Inc. All rights reserved.