Acute renal cortical necrosis caused by an antifibrinolytic drug (tranexamic acid)
Acute renal cortical necrosis caused by an antifibrinolytic drug (tranexamic acid)
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DOI：
10.1093/ndt/14.3.750
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发表时间：
1999-03-01
影响因子：
6.1
通讯作者：
Won, NH
中科院分区：
文献类型：
--
作者：
Koo, JR;Lee, YK;Won, NH
已有两份报告指出肾小球毛细血管弥漫性血管内凝血是导致皮质坏死的主要原因。我们也没有发现氨基己酸引起的血栓形成和皮质坏死[7，8]。在这些病例中，低血压的老年患者出现微血管病理性溶血性贫血的任何证据，如血细胞和网织红细胞增多，均为低血压的老年患者，这是缺血性肾损害的危险因素。然而，血迹涂抹。蛋白C、S蛋白水平正常，FANA、ANCA和冷球蛋白试验阴性，在本病例中，急性肾皮质坏死的发生在没有此类危险因素的情况下也排除了肾小球血栓形成和ARF的其他继发性原因。缺血性急性肾衰。已知正常出血时间、凝血酶原时间和抗纤溶药物对肾脏有不同的影响。Hruby等人[9]报道的部分凝血活酶时间似乎排除了脓毒症
There have been two reports of glomerular capillary with disseminated intravascular coagulation as a primary cause of cortical necrosis. We also could not find thrombosis and cortical necrosis caused by aminocaproic acid [7, 8]. In those cases, acute renal cortical any evidence of microangiopathic haemolytic anaemia, such as schistocytes and reticulocytosis, in a peripheral necrosis occurred in hypotensive elderly patients, which were risk factors for ischaemic renal insult. However, blood smear. Normal levels of protein C, protein S and negative FANA, ANCA and cryoglobulin tests in the present case, acute renal cortical necrosis developed in the absence of such risk factors for also ruled out other secondary causes of glomerular thrombosis and ARF. ischaemic ARF. The normal bleeding time, prothrombin time and Antifibrinolytic drugs have been known to exert variable effects on the kidney. Hruby et al.[9] reported partial thromboplastin time seemed to rule out sepsis