Transition metal complex-based smart AIEgens explored for cancer diagnosis and theranostics
Transition metal complex-based smart AIEgens explored for cancer diagnosis and theranostics
复制标题
DOI：
10.1016/j.ccr.2022.214822
复制
发表时间：
2022-12
影响因子：
20.6
通讯作者：
Lili Ma;Yao Wang;Xiuguang Wang;Qing Zhu;Yunli Wang;Luwei Li;Hong‐Bo Cheng;Jinchao Zhang
中科院分区：
文献类型：
--
作者：
Lili Ma;Yao Wang;Xiuguang Wang;Qing Zhu;Yunli Wang;Luwei Li;Hong‐Bo Cheng;Jinchao Zhang
生物成像在癌症诊断和治疗中发挥着重要作用。荧光成像技术是应用最广泛的生物成像技术之一。然而，传统的发光体通常遭受聚集引起的猝灭（ACQ）效应。自2001年Tang的里程碑式发现以来，聚集诱导发射发光体（AIEgens）已被广泛研究以克服这些缺点。基于过渡金属络合物的AIEgens（TM-AIEgens）联合收割机结合了有机AIEgens和过渡金属中心的优点，以改善生物物理性能和治疗结果。在此，我们重点介绍了TM-AIEgens应用于癌症诊断和治疗诊断学的最新进展。首先介绍了TM-AIEgens在肿瘤诊断中的应用，包括孤立癌细胞成像、肿瘤微环境响应成像、生物过程激活成像和肿瘤组织定位成像。然后介绍了TM-AIEgens用于不同类型的图像引导治疗，包括化疗、光动力学治疗（PDT）、光热治疗（PTT）、放疗和联合治疗。对于每一个例子，我们专注于结构设计，AIE活动的产生机制，以及诊断或治疗诊断性能。最后，我们讨论了TM-AIEgens当前面临的挑战和机遇。本文综述了TM-AIEgens在癌症诊断和治疗诊断中的应用，并将吸引更多的研究人员致力于这一领域。
Bioimaging plays an important role in cancer diagnosis and treatment. Fluorescence imaging (FI) is one of the most widely applied bioimaging technologies. However, the conventional luminophores usually suffer from the aggregation-caused quenching (ACQ) effect. The aggregation-induced emission luminogens (AIEgens) have been extensively investigated to combat these shortcomings since Tang’s landmark discovery in 2001. Transition metal complex-based AIEgens (TM-AIEgens) combine the advantages of organic AIEgens and transition metal centers to improve photophysical performance and therapeutic outcomes. Herein, we highlight the recent advances in TM-AIEgens applied for cancer diagnosis and theranostics. First, the TM-AIEgens applied for cancer diagnosis were introduced, including isolated cancer cell imaging, tumor microenvironment-responsive imaging, biological process-activated imaging, and tumor tissue-localized imaging. Then TM-AIEgens used for different types of image-guided therapy were presented, including chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), radiotherapy, and combination therapy. For each example, we focused on the structure design, the generation mechanism of AIE activity, and the diagnostic or theranostic performance. At last, we discussed the current challenges and opportunities for TM-AIEgens. This review gives a comprehensive landscape of TM-AIEgens in cancer diagnosis and theranostics and will engage more researchers to devote their efforts to this area.