Ultrasmall Pt Clusters Reducing Radiation-Induced Injuries via Scavenging Free Radicals
Ultrasmall Pt Clusters Reducing Radiation-Induced Injuries via Scavenging Free Radicals
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超小型铂簇通过清除自由基减少辐射引起的损伤
DOI：
10.1166/jbn.2017.2468
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发表时间：
2017
影响因子：
2.9
通讯作者：
Zhang Xiao Dong
中科院分区：
文献类型：
--
作者：
Xu Fujuan;Mu Xiaoyu;Wang Junying;Bian Peixian;Liu Lingfang;Liu Haile;Jing Yaqi;Long Wei;Liu Changlong;Zhang Xiao Dong
高能电离辐射在医学诊断和肿瘤放射治疗中有着广泛的应用。在治疗过程中，大剂量的X射线或γ射线会对癌组织和健康组织造成损害。因此，迫切需要开发化学制剂来保护健康组织免受高能射线的侵袭。在这里，超小的铂团簇被用作抗辐射剂，以保护健康细胞，提高受照射小鼠的存活率。研究发现，铂团簇可以减少照射后细胞的DNA损伤。体内实验表明，经铂簇合物处理后的受照小鼠存活率可提高30%以上。相比之下，只接受照射而没有接受铂簇治疗的小鼠在15天后完全死亡。详细的生物学实验表明，铂簇合物可以通过清除自由基恢复骨髓DNA水平和超氧化物歧化酶活性。重要的是，超小的铂团簇可以被肾脏快速排泄，不会造成长期毒性。
High energy ionizing radiation was widely used in medical diagnosis and cancer radiation therapy. The high dose of X ray or γ ray can cause the damage of cancerous tissue as well as healthy tissue during therapy. Therefore, it is urgent to develop chemical agents to protect the healthy tissue from high energy ray invasion. Here, the ultrasmall Pt clusters were employed as the anti-radiation agents for protecting healthy cells and improving survival rate of irradiated mice. It was found that Pt clusters can reduce the DNA damages in irradiated cells. In vivo experiments show that the Pt clusters treatment can improve the survival rate of irradiated mice up to 30%. As a contrast, only-irradiated mice without Pt clusters treatment completely died after 15 days. The detailed biological experiments showed that Pt clusters can recover the bone marrow DNA level and superoxide dismutase activities via scavenging free radicals. Importantly, the ultrasmall Pt clusters can be excreted rapidly by kidney and do not cause long-term toxicity.