Oral clindamycin and ciprofloxacin versus intramuscular ceftriaxone and oral doxycycline in the treatment of mild-to-moderate pelvic inflammatory disease in outpatients
Oral clindamycin and ciprofloxacin versus intramuscular ceftriaxone and oral doxycycline in the treatment of mild-to-moderate pelvic inflammatory disease in outpatients
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DOI：
10.1093/clinids/24.2.170
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发表时间：
1997-02-01
影响因子：
11.8
通讯作者：
Zambrano, D
中科院分区：
文献类型：
--
作者：
Arredondo, JL;Diaz, V;Zambrano, D
这项多中心、前瞻性、双盲研究比较了克林霉素和环丙沙星与头孢曲松和多西环素治疗腹腔镜诊断的轻中度盆腔炎（PID）门诊患者的安全性和有效性。治疗前和治疗后分别取宫颈内膜、子宫内膜和腹腔标本进行需氧菌、厌氧菌、淋病奈瑟菌和沙眼衣原体培养。在入组的138例患者中，131例可评估疗效。最常见的细菌是链球菌、葡萄球菌和大肠杆菌（在需氧菌中），以及拟杆菌和胃链球菌（在厌氧菌中）。在131例可评估的患者中，2%（3例）存在淋病奈瑟菌，11%（15例）存在沙眼奈瑟菌。克林霉素联合环丙沙星组临床治愈率为97%(67 / 65)，头孢曲松联合强力霉素组临床治愈率为95%（64 / 61）。两组的副作用相似。总之，两种方案对轻中度PID的门诊治疗同样有效和安全。
This multicenter, prospective, double-blind study compared the safety and efficacy of clindamycin and ciprofloxacin versus ceftriaxone and doxycycline in the treatment of outpatients with mild to moderate pelvic inflammatory disease (PID) diagnosed by laparoscopy. Samples taken from the endocervix, endometrium, and abdominal cavity before treatment and from the endocervix after treatment were cultured for aerobes, anaerobes, Neisseria gonorrhoeae, and Chlamydia trachomatis. Of the 138 patients enrolled, 131 were evaluable for efficacy. The most prevalent bacteria were streptococci, staphylococci, and Escherichia coli (among aerobes) and Bacteroides species and peptostreptococci (among anaerobes). N. gonorrhoeae was present in 2% (3) of the 131 evaluable patients, and C. trachomatis was in 11% (15). The clinical cure rate was 97% (65 of 67) in the clindamycin and ciprofloxacin group and 95% (61 of 64) in the ceftriaxone and doxycycline group. Side effects were similar in both groups. In conclusion, the two regimens for the outpatient treatment of mild to moderate PID were similarly effective and safe.