Status of Glucocorticoid Alterations in Post-traumatic Stress Disorder
Status of Glucocorticoid Alterations in Post-traumatic Stress Disorder
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DOI：
10.1111/j.1749-6632.2009.04979.x
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Yehuda, Rachel
中科院分区：
文献类型：
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作者：
Yehuda, Rachel
本章将介绍创伤后应激障碍（PTSD）中糖皮质激素改变的现状。重点将放在数据表明，至少有一些糖皮质激素相关的观察PTSD反映创伤前糖皮质激素的状态。最近的观察提供了一些证据表明，创伤前糖皮质激素的改变可能来自遗传，表观遗传，以及可能的其他环境影响，这些影响有助于增加创伤暴露后发生PTSD的可能性，以及调节与其病理生理学相关的伴随生物学改变。目前PTSD领域的研究采用糖皮质激素激发策略来描述外源性糖皮质激素对神经内分泌、认知和脑功能的影响。这些研究的结果提供了一个重要的理由，使用糖皮质激素的策略在治疗创伤后应激障碍。
The current status of glucocorticoid alterations in post-traumatic stress disorder (PTSD) will be described in this chapter. Emphasis will be placed on data that suggest that at least some glucocorticoid-related observations in PTSD reflect pretraumatic glucocorticoid status. Recent observations have provided some evidence that pretraumatic glucocorticoid alterations may arise from genetic, epigenetic, and possibly other environmental influences that serve to increase the likelihood of developing PTSD following trauma exposure, as well as modulate attendant biological alterations associated with its pathophysiology. Current studies in the field of PTSD employ glucocorticoid challenge strategies to delineate effects of exogenously administered glucocorticoids on neuroendocrine, cognitive, and brain function. Results of these studies have provided an important rationale for using glucocorticoid strategies in the treatment of PTSD.