An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency in Primary Human CD4+ T Cells.
An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency in Primary Human CD4+ T Cells.
复制标题
模拟人类原代 CD4 T 细胞中 HIV-1 潜伏期的建立和重新激活的体外系统。
DOI：
10.1007/978-1-0716-1871-4_3
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Romerio,Fabio
中科院分区：
文献类型：
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作者：
Li,Rui;Romerio,Fabio
HIV-1 establishes latency primarily by infecting activated CD4+ T cells that later return to quiescence as memory cells. Latency allows HIV-1 to evade immune responses and to persist during antiretroviral therapy, which represents an important problem in clinical practice. Here we describe both the original and a simplified version of HIV-1 latency models that mimics this process using replication competent viruses. Our model allows generation of large numbers of latently infected CD4+ T cell to dissect molecular mechanisms of HIV latency and reactivation.
