Valence and salience contribute to nucleus accumbens activation
Valence and salience contribute to nucleus accumbens activation
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DOI：
10.1016/j.neuroimage.2007.08.009
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发表时间：
2008-01-01
期刊：
影响因子：
5.7
通讯作者：
Knutson, Brian
中科院分区：
文献类型：
--
作者：
Cooper, Jeffrey C.;Knutson, Brian
对伏隔核（NAcc）功能的不同解释强调了它在激励预期期间代表效价或显着性的作用。在一项与事件相关的 FMRI 实验中，我们通过提示参与者预测某些和不确定的货币收益和损失来独立操纵效价和显着性。 NAcc 激活与效价和显着性相关。在具有某些结果的试验中，NAcc 激活因预期收益而增加，而因预期损失而减少。在结果不确定的试验中，NAcc 激活对于预期收益和损失均有所增加，但它们之间没有差异。这些发现表明 NAcc 激活分别代表效价和显着性，与其在食欲动机中的假设作用一致。 (C) 2007 Elsevier Inc. 保留所有权利。
Different accounts of nucleus accumbens (NAcc) function have emphasized its role in representing either valence or salience during incentive anticipation. In an event-related FMRI experiment, we independently manipulated valence and salience by cuing participants to anticipate certain and uncertain monetary gains and losses. NAcc activation correlated with both valence and salience. On trials with certain outcomes, NAcc activation increased for anticipated gains and decreased for anticipated losses. On trials with uncertain outcomes, NAcc activation increased for both anticipated gains and losses but did not differ between them. These findings suggest that NAcc activation separately represents both valence and salience, consistent with its hypothesized role in appetitive motivation. (C) 2007 Elsevier Inc. All rights reserved.