The effect of the floor plate on pattern and polarity in the developing central nervous system.
The effect of the floor plate on pattern and polarity in the developing central nervous system.
复制标题
地板对发育中的中枢神经系统的模式和极性的影响。
DOI：
10.1126/science.1987648
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Sohal,GS
中科院分区：
文献类型：
--
作者：
Hirano,S;Fuse,S;Sohal,GS
研究了底板对鹌鹑胚胎神经管内细胞分化的影响。在发育中的神经管中，底板位于神经管的腹中线，由特化的神经上皮细胞组成。摘除Hensen‘s结时，底板和脊索不发育，腹角运动神经元和背根、腹根不能正常分化。当神经管一侧失去脊索时，两侧发生腹背分化。但是，当神经管的一侧失去底板时，该侧的腹角运动神经元以及背根和腹根都不发育。这些观察表明，底板影响运动神经元的分化，并作为一种内在的组织者，在发育中的神经系统中建立模式和极性。
The effect of floor plate on cellular differentiation in the neural tube of quail embryos was examined. In the developing neural tube the floor plate, which consists of specialized neuroepithelial cells, is located in the ventral midline of the neural tube. When Hensen's node was extirpated the floor plate and notochord did not develop, and the normal differentiation of the ventral horn motor neurons and dorsal and ventral roots did not occur. When one side of the neural tube was deprived of notochord, the ventro-dorsal differentiation took place on both sides. However, when one side of the neural tube was deprived of the floor plate, the ventral horn motor neurons and dorsal and ventral roots did not develop on that side. These observations suggest that the floor plate influences motor neuron differentiation and acts as an intrinsic organizer to establish pattern and polarity in the developing nervous system.