Cdk2 as a Master of S phase Entry: Fact or Fake?
Cdk2 as a Master of S phase Entry: Fact or Fake?
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DOI：
10.4161/cc.3.1.632
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发表时间：
2004-01
期刊：
影响因子：
4.3
通讯作者：
E. Aleem;C. Berthet;P. Kaldis
中科院分区：
文献类型：
--
作者：
E. Aleem;C. Berthet;P. Kaldis
长期以来，人们一直认为Cdk 2及其激活剂cyclin E在有丝分裂细胞周期的进程中发挥重要作用。然而，最近使用敲除小鼠模型的研究表明，Cdk2和细胞周期蛋白E在体内都不是必需的。本综述的目的是比较Cdk2和cyclin E基因敲除小鼠模型，并讨论在缺乏Cdk2或cyclin E的情况下驱动细胞周期的潜在机制。特别强调的是放在可能的非催化作用的细胞周期蛋白E，表达和活性的第二个细胞周期蛋白结合的合作伙伴的Cdk2，细胞周期蛋白A，以及对表达和降解的Cdk2抑制剂p27 Kip1在Cdk2的情况下。
It has long been believed that Cdk2 and its activator cyclin E play essential roles in the progression of the mitotic cell cycle. However, recent studies using knockout mouse models revealed that neither Cdk2 nor cyclin E are essential in vivo. The purpose of this mini-review is to compare both Cdk2 and cyclin E knockout mice models and to discuss potential mechanisms driving the cell cycle in the absence of Cdk2 or cyclin E. Particular emphasis is placed on possible non-catalytic roles of cyclin E, the expression and activity of the second cyclin binding partner of Cdk2, cyclin A, as well as on the expression and degradation of the Cdk2 inhibitor p27Kip1 in the absence of Cdk2.