Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis
Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis
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DOI：
10.1183/09031936.00178508
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发表时间：
2009-09-01
影响因子：
24.3
通讯作者：
Upham, J. W.
中科院分区：
文献类型：
--
作者：
Brennan, S.;Sly, P. D.;Upham, J. W.
气道炎症是囊性纤维化（CF）肺部疾病的重要组成部分。我们试图确定肺泡巨噬细胞是否参与早期CF肺病。CF患儿（中位年龄3.1岁）参加了一项监测计划，包括每年支气管肺泡灌洗（BAL）。对照样本来自非cf儿童（中位年龄3.1岁，n=24），调查持续呼吸道症状。CF组和非CF组分别有31%（51人中16人）和38%（24人中9人）的儿童检测到肺部感染。在没有感染的情况下，CF患者与非CF患者相比，BAL中的肺泡巨噬细胞增加(223 × 10(3)比85 × 10(3)个细胞。ml (-1)；p=0.001)，并与CC趋化因子(巨噬细胞炎症蛋白(MIP)-3 α(趋化因子（C-C基序）配体（CCL）20；355.8 vs 46.0 pg.mL(-1)；p
Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease.Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n=24) investigated for persistent respiratory symptoms.Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223 x 10(3) versus 85 x 10(3) cells.mL(-1); p=0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3 alpha (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg.mL(-1); p