Vesicle Movements and Microtubule-Based Motors
Vesicle Movements and Microtubule-Based Motors
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DOI：
10.1242/jcs.1986.supplement_5.11
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发表时间：
1986-02
影响因子：
4
通讯作者：
M. Sheetz;R. Vale;B. Schnapp;T. Schroer;T. Reese
中科院分区：
文献类型：
--
作者：
M. Sheetz;R. Vale;B. Schnapp;T. Schroer;T. Reese
许多细胞质囊泡的运动遵循微管的路径，在同一微管上，一些向一个方向运动，另一些向相反方向运动。最近，我们已经分离出一个细胞质马达，驱动蛋白，并定义了另一个，轴浆逆行因子，这两个都能够供电阴离子乳胶珠在两个方向沿着极性微管阵列。这里总结的证据支持但不能证明驱动蛋白和逆行马达确实负责驱动囊泡运动的假设。
SUMMARY The movements of many cytoplasmic vesicles follow the paths of microtubules, some moving in one direction and others moving in the opposite direction on the same microtubule. Recently we have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, both of which are capable of powering anionic latex beads in both directions along polar microtubule arrays. Evidence summarized here supports but does not prove the hypothesis that kinesin and the retrograde motors are indeed responsible for powering vesicle movements.