PATTERNS OF BREATHING IN RESPONSE TO ALTERNATING PATTERNS OF ALVEOLAR CARBON-DIOXIDE PRESSURES IN MAN
PATTERNS OF BREATHING IN RESPONSE TO ALTERNATING PATTERNS OF ALVEOLAR CARBON-DIOXIDE PRESSURES IN MAN
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DOI：
10.1113/jphysiol.1986.sp016140
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发表时间：
1986-07-01
影响因子：
5.5
通讯作者：
PETERSEN, ES
中科院分区：
文献类型：
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作者：
CUNNINGHAM, DJC;HOWSON, MG;PETERSEN, ES
1.呼吸周期内肺泡PCO2的时间曲线被迫以两种不同的方式遵循交替呼吸中的对比模式。呼吸内变化（w.b.c.，在交替吸气的早期或晚期提供富含CO2的吸气）涉及潮气末PCO2的最小改变。呼吸间变化（b.b.c.，全部吸入无CO2或富含CO2的气体）涉及潮气末PCO2的大幅波动。如先前所报道的（Metias、Cunningham、Howson、Petersen和Wolff，1981年），两种强迫模式都与换气交替有关，但仅在存在缺氧时。2.本文报道了四名人体在稳定低氧条件下118次呼吸交替反射反应的模式，包括吸气和呼气潮气量、时间和平均流量的交替变化。这些模式往往消失，或在中期不可预测地改变。3.反射交替的吸气模式部分取决于强迫的类型，但吸气潮气量的交替通常与两种类型。4.没有单一的模式呼气交替出现的优势。5.令人惊讶的是，反射性呼气交替的模式与吸气交替的模式无关：事实上，w.b.c.，但不是在不列颠哥伦比亚省，平均呼气流量和平均吸气流量的交替是相互排斥的。6.它的结论是，在人，在猫和狗，动脉化学感受器通路已进入呼吸模式发生器的各个部分，确切的反应在一定程度上取决于呼吸周期内的时间。特别是，呼气变量可能直接通过动脉化学感受器途径受到影响，即没有任何假定介导的吸气交替被证明。7.结果进行了简要的讨论有关的一些目前的看法，呼吸控制的组织。
1. The time profile of alveolar PCO2 within the respiratory cycle has been forced to follow contrasting patterns in alternate breaths, in two different ways. Within-breath changes (w.b.c., with a CO2-rich inspirate supplied early or late in alternate inspirations) involved minimal alteration of end-tidal PCO2. Between-breath changes (b.b.c., with whole inspirates of CO2-free or CO2-rich gas) involved large swings of end-tidal PCO2. As previously reported (Metias, Cunningham, Howson, Petersen and Wolff, 1981), both patterns of forcing were associated with alternation of ventilation, but only when hypoxia was present. 2. The patterns of the alternating reflex responses in 118 runs on four human subjects in steady hypoxia are described in terms of alternation of inspiratory and expiratory tidal volume, time and mean flow. These patterns often disappeared, or changed unpredictably in mid-run. 3. The inspiratory pattern of reflex alternation depended in part on the type of forcing, but alternation of inspiratory tidal volume was usually observed with both types. 4. No single pattern of expiratory alternation emerged as predominant. 5. The pattern of reflex expiratory alternation was surprisingly independent of the pattern of inspiratory alternation: indeed, w.b.c., but not in b.b.c., alternation of mean expiratory flow and of mean inspiratory flow were mutually exclusive. 6. It is concluded that in man, as in cats and dogs, the arterial chemoreceptor pathway has access to various parts of the respiratory pattern generator, the exact response depending to some extent on the timing within the respiratory cycle. In particular, expiratory variables may be influenced directly through the arterial chemoreceptor pathway, i.e. without any supposedly mediating inspiratory alternation being demonstrable. 7. The results are discussed briefly in relation to some current views on the organization of respiratory control.