Low protein Z plasma levels are independently associated with acute coronary syndromes
Low protein Z plasma levels are independently associated with acute coronary syndromes
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DOI：
10.1160/th03-04-0237
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发表时间：
2003-12-01
影响因子：
6.7
通讯作者：
Gensini, GF
中科院分区：
文献类型：
--
作者：
Fedi, S;Sofi, F;Gensini, GF
蛋白Z（PZ）是由肝脏合成的单链维生素K依赖性糖蛋白。体内和体外研究表明，PZ在抑制凝血方面起着重要作用，因为它通过与血浆PZ依赖性蛋白酶抑制剂形成复合物而作为因子Xa失活的辅因子。最近，关于缺血性卒中患者血浆PZ水平的研究结果相互矛盾，本研究旨在探讨PZ在急性冠状动脉综合征（ACS）中的作用。在223名（189名男性; 34名女性）ACS患者（参考佛罗伦萨大学冠脉强化治疗中心）和265名（219名男性; 46名女性）健康受试者中测定PZ血浆水平。排除口服抗凝治疗的患者以及抗磷脂抗体阳性的受试者。无肝肾功能障碍。患者的平均PZ血浆水平（1508 +/- 730 ng/mL）低于对照组（1728 +/- 594 ng/mL）（p < 0.0001）。15.7%的患者和4.9%的对照组PZ水平低于正常值分布的第5百分位数（565 ng/mL）（p
Protein Z (PZ) is a single chain vitamin-K-dependent glycoprotein synthesized by the liver. Studies in vivo and in vitro suggest that PZ plays an important role in inhibiting coagulation as it serves as cofactor for the inactivation of factor Xa by forming a complex with the plasma PZ-dependent protease inhibitor. Recently, conflicting findings on plasma PZ levels in patients with ischemic stroke have been published.Aim of our study was to investigate the role of PZ in acute coronary syndromes (ACS). PZ plasma levels were determined in 223 (189 M; 34 F) patients with ACS referring to the Coronary Intensive Therapy Unit of University of Florence and in 265 (219 M; 46 F) healthy subjects. Patients under oral anticoagulation treatment as well as subjects with positivity for antiphospholipid antibodies were excluded. None had liver or kidney dysfunction. The mean PZ plasma level was lower in patients (1508 +/- 730 ng/mL) than in controls (1728 +/- 594 ng/mL) (p < 0.0001). PZ levels below the 5(th) percentile (565 ng/mL) of normal values distribution in control subjects were found in 15.7% of patients and in 4.9% of controls (p