Hippocampal volume reduction in 22q11.2 deletion syndrome
Hippocampal volume reduction in 22q11.2 deletion syndrome
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DOI：
10.1016/j.neuropsychologia.2006.05.006
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Eliez, Stephan
中科院分区：
文献类型：
--
作者：
Debbane, Martin;Schaer, Marie;Eliez, Stephan
海马体积减少和记忆能力下降形成了精神分裂症中观察到的特征性神经功能改变。受22q11.2缺失综合征（22 q11 DS）影响的个体，虽然在整个发育过程中表现出记忆缺陷，但也有患精神分裂症的高风险。本研究旨在调查海马体积减少作为单独的全球灰质减少在一个大的，独立的样本与22 q11 DS的个人。从结构磁共振成像获得的体积数据为43人受影响的22 q11 DS，年龄在6-39岁，以及40名健康人的年龄和性别相匹配。包括杏仁核的绘制以增强海马体的描绘，并且使用增加的分辨率矩阵执行杏仁核和海马体的划界。在控制受影响个体中观察到的总灰体积减少后，在22 q11 DS组中观察到海马体积显著减少，这是由海马体的显著双侧体积减少驱动的。这些结果进行了讨论，在参考记忆和大脑的改变已经报道在22 q11 DS。此外，海马体体积减小的具体影响概述了其解剖关系和记忆功能。最后，在与缺失相关的精神病风险状态的背景下，检查22 q11 DS中海马体积的减少。(c)2006爱思唯尔有限公司版权所有。
Hippocampal volume reduction and decreased memory skills form a characteristic neurofunctional alteration observed in schizophrenia. Individuals affected with 22q 11.2 deletion syndrome (22q11DS), while exhibiting memory deficits throughout development, are also at high risk for developing schizophrenia. The present study sought to investigate hippocampal volume reduction as separate of global grey matter reduction in a large, independent sample of individuals with 22q11DS. Volurnetric data from structural magnetic resonance imaging was obtained for 43 individuals affected with 22q11DS, aged 6-39 years of age, as well as for 40 healthy individuals matched for age and gender. Drawing of the amygdala was included to enhance the delineation of the hippocampus, and circumscription of both the amygdala and the hippocarnpus were executed using an increased resolution matrix. After controlling for total grey volume reductions observed in affected individuals, a significant decrease in hippocampus volume was observed in the 22q11DS group, driven by significant bilateral volumetric reduction of the body of the hippocampus. These results are discussed in reference to memory and cerebral alterations already reported in 22q11DS. Further, the specific implications of hippocampus body volume reduction are outlined in light of its anatomical relationships and its function in memory. Finally, reduction of hippocampal volume in 22q11DS is examined in the context of psychiatric risk status associated to the deletion. (c) 2006 Elsevier Ltd. All rights reserved.