Constitutive androstane receptor (CAR) mediates pyrene‐induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells
Constitutive androstane receptor (CAR) mediates pyrene‐induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells
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DOI：
10.1111/bph.15934
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发表时间：
2022-07
影响因子：
7.3
通讯作者：
Zhe Shi;Xue Li;Yu-Man Zhang;Yi‐Yao Zhou;Xiu-Feng Gan;Qiao‐Ying Fan;Chen-Qing He;Tong Shi;Shu-Yun Zhang
中科院分区：
文献类型：
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作者：
Zhe Shi;Xue Li;Yu-Man Zhang;Yi‐Yao Zhou;Xiu-Feng Gan;Qiao‐Ying Fan;Chen-Qing He;Tong Shi;Shu-Yun Zhang
组成型雄甾烷受体（CAR）是一种已知的异生物质感受器，通过调控多种基因在药物代谢中发挥重要作用。多环芳烃芘是一种环境污染物，是CAR激活剂，通过CAR诱导小鼠肝毒性。在这里，我们研究了芘引起的小鼠肝损伤中炎症反应的分子机制。
The constitutive androstane receptor (CAR), a known xenobiotic sensor, plays an important role in drug metabolism by regulating numerous genes. The polycyclic aromatic hydrocarbon pyrene, an environmental pollutant, is a CAR activator and induces mouse hepatotoxicity via CAR. Here, we investigate the molecular mechanisms of the inflammatory response in pyrene‐caused mice liver injury.