Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases
Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases
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DOI：
10.1016/j.burns.2008.01.014
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发表时间：
2008-09-01
期刊：
影响因子：
2.7
通讯作者：
Karimi, Hamid
中科院分区：
文献类型：
--
作者：
Barati, Mitra;Alinejad, Faranak;Karimi, Hamid
脓毒症的诊断是困难的，特别是在烧伤的情况下，在没有真实的感染的情况下可能存在脓毒症的迹象。本研究比较了60例烧伤合并感染者与非感染者血清降钙素原（PCT）、C反应蛋白（CRP）、血沉（ESR）及白色血细胞（WBC）的变化，以评价其对脓毒症的诊断价值。脓毒症组的PCT水平显著高于非脓毒症组（分别为8.45 +/- 7.8 vs. 0.5 +/- 1.0，p < 0.001）; CRP或WBC水平、中性粒细胞计数或ESR无显著差异。PCT诊断脓毒症的受试者工作特征曲线下面积为0.97（p < 0.001），敏感性为100%，特异性为89.3%。非幸存者的平均PCT水平显著高于幸存者。PCT是诊断烧伤后严重感染性并发症的有效指标，而WBC、中性粒细胞、ESR和CRP的诊断价值不大。(C)2008 Elsevier Ltd和ISBI。All rights reserved.
Diagnosis of sepsis is difficult, particularly in cases of burn where signs of sepsis may be present in the absence of a real infection. This study compared serum levels of procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell (WBC) among 60 burned people with and without infection, in order to assess the value of the information for diagnosis of sepsis. A significantly higher PCT level was observed in the septic group compared to those without sepsis (8.45 +/- 7.8 vs. 0.5 +/- 1.0, respectively, p < 0.001); no significant differences were found in CRP or WBC levels, neutrophil count or ESR. The area under the receiver operating characteristics curve in the diagnosis of sepsis was 0.97 for PCT (p < 0.001) with sensitivity of 100% and specificity of 89.3%. Non-survivors had a mean PCT level significantly higher than that of survivors. Thus the serum PCT level was a highly efficient laboratory parameter for the diagnosis of severe infectious complications after burn, but WBC, neutrophil, ESR and CRP levels were of little value. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.