Type IV secretion system of Brucella spp. and its effectors.
Type IV secretion system of Brucella spp. and its effectors.
复制标题
布鲁氏菌属 IV 型分泌系统。
DOI：
10.3389/fcimb.2015.00072
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发表时间：
2015
影响因子：
5.7
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Ke Y;Wang Y;Li W;Chen Z
布鲁氏菌是引起家畜和野生动物感染的细胞内细菌病原体。它们经常被用作研究细胞内细菌感染的模式生物。布鲁氏菌VirB T4SS是一种重要的毒力因子，在介导细胞内存活和操纵宿主对感染的免疫应答中起重要作用。在这篇综述中，我们讨论了布鲁氏菌VirB T4SS和15个效应器的作用，提出是至关重要的布鲁氏菌发病机制。VirB T4SS调节炎症反应并操纵宿主细胞内的囊泡运输。VirB T4SS还在感染期间抑制宿主免疫应答和细胞内存活中起关键作用。在这里，我们列出了布鲁氏菌细胞内生命周期中的关键分子事件，这些事件可能被VirB T4SS效应子靶向。阐明这些效应子的功能将有助于阐明T4SS在感染过程中的分子作用。此外，研究布鲁氏菌分泌的效应子。这可能有助于了解细菌劫持宿主信号通路的机制，并有助于开发更好的布鲁氏菌病疫苗和治疗方法。
Brucella spp. are intracellular bacterial pathogens that cause infection in domestic and wild animals. They are often used as model organisms to study intracellular bacterial infections. Brucella VirB T4SS is a key virulence factor that plays important roles in mediating intracellular survival and manipulating host immune response to infection. In this review, we discuss the roles of Brucella VirB T4SS and 15 effectors that are proposed to be crucial for Brucella pathogenesis. VirB T4SS regulates the inflammation response and manipulates vesicle trafficking inside host cells. VirB T4SS also plays crucial roles in the inhibition of the host immune response and intracellular survival during infection. Here, we list the key molecular events in the intracellular life cycle of Brucella that are potentially targeted by the VirB T4SS effectors. Elucidating the functions of these effectors will help clarify the molecular role of T4SS during infection. Furthermore, studying the effectors secreted by Brucella spp. might provide insights into the mechanisms used by the bacteria to hijack the host signaling pathways and aid in the development of better vaccines and therapies against brucellosis.