USE OF JOB-EXPOSURE MATRIX IN AN OCCUPATIONAL ANALYSIS OF LUNG AND BLADDER CANCERS ON THE BASIS OF DEATH CERTIFICATES
USE OF JOB-EXPOSURE MATRIX IN AN OCCUPATIONAL ANALYSIS OF LUNG AND BLADDER CANCERS ON THE BASIS OF DEATH CERTIFICATES
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DOI：
10.1093/jnci/72.1.61
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
ACHESON, ED
中科院分区：
文献类型：
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作者：
COGGON, D;PANNETT, B;ACHESON, ED
工作接触矩阵已被应用于肺癌和膀胱癌的病例对照研究的基础上，从英国死亡证明中提取的职业信息。肺癌和工作接触石棉之间的预期关联得到了明确的证明（相对危险度，1.5; 95%置信区间，1.2-1.9）。其他三种已知的工业致癌物的影响并不明显，并讨论了原因。矩阵中还包括五种对人类致癌性尚未确定的物质。甲醛、柴油烟雾和切削油都与支气管癌有关，但在“高暴露”职业中没有风险是反对因果关系的。膀胱癌在接触印刷油墨（相对危险度，5.0; 95%置信区间，1.0-25.8）和切削油（相对危险度，1.5; 95%置信区间，0.8-2.8）的工作中更常见。工作接触矩阵的使用大大增加了对个别职业类别癌症风险的传统分析。
A job-exposure matrix has been applied in a case-control study of lung and bladder cancer on the basis of occupational information abstracted from British death certificates. The expected association between lung cancer and jobs entailing exposure to asbestos was clearly demonstrated (relative risk, 1.5; 95% confidence interval, 1.2–1.9). The effects of three other known industrial carcinogens were not apparent, and reasons for this were discussed. Also included in the matrix were five substances whose carcinogenicity in humans has not been established. Formaldehyde, diesel fumes, and cutting oils were all associated with carcinoma of the bronchus, but the absence of a risk in “high-exposure” occupations was against a causal relationship. Bladder cancer was more common in jobs involving high exposure to printing inks (relative risk, 5.0; 95% confidence interval, 1.0–25.8) and cutting oils (relative risk, 1.5; 95% confidence interval, 0.8–2.8). Use of the job-exposure matrix added considerably to the conventional analysis of cancer risk in individual occupational categories.