Time trends in breast cancer survival: experience in a single centre, 1975-89
Time trends in breast cancer survival: experience in a single centre, 1975-89
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DOI：
10.1038/bjc.1998.322
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发表时间：
1998-06-01
影响因子：
8.8
通讯作者：
Rubens, RD
中科院分区：
文献类型：
--
作者：
Bradburn, MJ;Altman, DG;Rubens, RD
这项回顾性队列研究的目的是调查1975- 1989年间乳腺癌患者的生存率是否发生了变化。在伦敦一家临床肿瘤科，共有2604名被诊断为浸润性乳腺癌的女性接受了5至20年的随访。根据月经状况（术前或术后）和癌症分期（可手术或不可手术）将患者分为四组。对于每一组，在三个连续的5年队列中比较诊断后的生存率，包括对相关预后因素进行调整和不进行调整。在不能手术的癌症患者中没有发现时间模式，这些患者的存活率一直很低。在可手术的癌症患者中，只有绝经后的女性存在差异，在1985- 1989年间诊断出的患者中，她们的生存模式最好。这可能是由于他莫昔芬通常被作为辅助治疗处方用于这组患者。我们无法解释在20世纪80年代早期出现的患者与在20世纪70年代末观察到的患者相比明显更差的生存率。
The aim of this retrospective cohort study was to investigate whether survival of patients with breast cancer has changed over the period 1975-89. A total of 2604 women diagnosed as having invasive breast cancer at a clinical oncology unit in London were followed up for between 5 and 20 years. Patients were divided into four groups according to menstrual status (pre or post) and the staging of cancer (operable or inoperable). For each group, survival from diagnosis was compared between three consecutive 5-year cohorts, both with and without adjustments made for relevant prognostic factors. No temporal patterns were found in patients with inoperable cancer, in whom the survival rate was consistently low. Of women with operable cancers, differences were seen only among post-menopausal women, for whom the best survival patterns were seen in patients diagnosed between 1985-89. This is probably due to tamoxifen being commonly prescribed as adjuvant treatment for this cohort of patients. We cannot explain an apparently worse survival in the group of patients presenting in the early 1980s compared with that observed in the late 1970s.