Addiction to apomorphine: a clinical case-centred discussion.
Addiction to apomorphine: a clinical case-centred discussion.
复制标题
阿扑吗啡成瘾：以临床病例为中心的讨论。
DOI：
10.1111/j.1360-0443.2006.01580.x
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发表时间：
2006
期刊：
影响因子：
6
通讯作者：
P. Venegas
中科院分区：
文献类型：
--
作者：
C. Téllez;M. Bustamante;P. Toro;P. Venegas
目标
报告一例患者，在抗帕金森病治疗的背景下，对阿朴吗啡上瘾。
方法
临床病例描述。
结果
阿朴吗啡是一种直接作用于D2受体的多巴胺能激动剂。它已被用于酒精中毒、男性性功能障碍以及帕金森氏病(PD)的诊断和治疗。
结论
本研究描述了一例帕金森病妇女，她对阿朴吗啡的摄取失去了控制，导致她的功能严重受损。高发的帕金森病患者会出现不同的精神症状。相反，抗帕金森症药物还会产生精神症状，患者可能会体验到愉悦的感觉(“警觉”、“觉醒”、“激活”、轻躁狂和性欲亢奋)。尽管如此，帕金森病患者对这些药物的上瘾是非常罕见的现象。目前，阿朴吗啡的处方已扩展到勃起功能障碍患者，这可能会增加成瘾病例或严重精神症状的患病率。
AIM
To report the case of a patient, who in the context of an anti-Parkinsonian therapy, developed addiction to apomorphine.
METHODS
Clinical case description.
RESULTS
Apomorphine is a dopaminergic agonist that acts directly on D2 receptors. It has been used in alcoholism, male sexual dysfunction and with diagnostic and therapeutic purposes in Parkinson's disease (PD).
CONCLUSIONS
The present work describes the case of a woman with PD who developed a loss of control over the consumption of apomorphine that resulted in a significant impairment of her functioning. PD patients with high frequency develop different psychiatric symptoms. Conversely, anti-Parkinsonian drugs also generate psychiatric symptoms that can be experienced by the patient as pleasant sensations ('alerting', 'awakening', 'activating', hypomania and hypersexuality). In spite of this, addiction to these drugs in patients with PD is a very rare phenomenon. Currently, the prescription of apomorphine has been extended to patients with erectile dysfunction, which may increase the prevalence of addiction cases or of severe psychiatric symptoms.