Carrier detection in hemophilia A: a cooperative international study. II. The efficacy of a universal discriminant.
Carrier detection in hemophilia A: a cooperative international study. II. The efficacy of a universal discriminant.
复制标题
A 型血友病携带者检测：一项国际合作研究。
作者：
P. Green;P. Mannucci;E. Briet;R. Ljung;C. Kasper;E. Essien;J. Chediak;C. Rizza;J. Graham
因子VIII（F.VIII）和von Willebrand因子（VWF）：Ag数据收集的8个实验室共336强制性血友病A和137名正常妇女的载体被用来回答几个问题，关于建设的线性判别载体检测。结果发现：可以构建适用于所有实验室且几乎与实验室特异性判别式一样有效“通用”线性判别式;包括年龄和ABO血型数据改善了这些判别式的功效;与使用F.VIII：C的生物测定和VWF：Ag的Laurell免疫测定获得的判别式相比，替代F.VIII：C和VWF：Ag的替代测定通常不会改善判别式的功效;线性判别法比基于F.VIII：C/VWF：Ag比率的判别法有效得多。给出了一个逐步的程序，任何实验室都可以遵循使用的通用判别载波检测。
Factor VIII (F.VIII) and von Willebrand factor (VWF):Ag data collected by eight laboratories on a total of 336 obligatory carriers of hemophilia A and 137 normal women were used to answer several questions concerning the construction of linear discriminants for carrier detection. It was found: that a "universal" linear discriminant can be constructed which is suitable for use in all laboratories and is nearly as effective as laboratory-specific discriminants; that inclusion of age and ABO blood type data improved the efficacy of these discriminants; that substitution of alternative assays for F.VIII and VWF:Ag did not generally improve the efficacy of the discriminants over that obtained using the bioassay for F.VIII:C and Laurell's immunoassay for VWF:Ag; that linear discriminants were far more effective than discriminants based on the F.VIII:C/VWF:Ag ratio. A step-wise procedure is given which any laboratory may follow in using the universal discriminant for carrier detection.
妊娠期间血友病携带者的检测。
影响因子：
20.3
作者：
Hoyer,LW;Carta,CA;Mahoney,MJ
通讯作者：
Mahoney,MJ
通过免疫放射分析对经典血友病（血友病 A）进行产前诊断。
影响因子：
20.3
作者：
Hoyer,LW;Carta,CA;Golbus,MS;Hobbins,JC;Mahoney,MJ
通讯作者：
Mahoney,MJ