Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis
Phthalate exposure through different pathways and allergic sensitization in preschool children with asthma, allergic rhinoconjunctivitis and atopic dermatitis
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DOI：
10.1016/j.envres.2015.01.012
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发表时间：
2015-02-01
影响因子：
8.3
通讯作者：
Clausen, Geo
中科院分区：
文献类型：
--
作者：
Beko, Gabriel;Callesen, Michael;Clausen, Geo
对啮齿动物的研究表明，邻苯二甲酸酯可以作为佐剂，增加过敏原的效力。同时，流行病学研究对邻苯二甲酸酯暴露与人类过敏性疾病之间的关系产生了不一致的结果。本研究检查了一大群3-5岁儿童的邻苯二甲酸酯暴露和过敏性致敏性：300例随机对照和200例哮喘、鼻结膜炎或特应性皮炎病例，如问卷调查所报告。对这些儿童进行了临床检查，以确认他们的健康状况。分析血液样品对20种过敏原的IgE致敏性。调整后的逻辑回归用于寻找邻苯二甲酸酯暴露指标（来自儿童家庭和日托所的灰尘中的质量分数，尿液中的代谢物，以及估计的每日室内摄入量（来自灰尘摄入，吸入和皮肤吸收））与致敏和过敏性疾病之间的关联。邻苯二甲酸酯暴露与哮喘、鼻结膜炎或特应性皮炎之间没有直接联系。然而，在患有这些疾病的儿童中，室内环境中DnBP、BBzP和DEHP的非膳食暴露（灰尘中的质量分数或每日室内摄入量，来自灰尘摄入、吸入和皮肤吸收）与过敏性致敏之间存在显著关联。某些接触途径与致敏作用的相关性比其他途径更强，但结果并非结论性的，需要确认。一些关联依赖于对儿童在一个以上环境中的暴露的解释（即，家庭和日托设施）。尿液中的邻苯二甲酸酯代谢物（反映了饮食和室内途径的暴露）与过敏性致敏反应之间未观察到显著相关性。(C)2015 Elsevier Inc. All rights reserved.
Studies in rodents indicate that phthalates can function as adjuvants, increasing the potency of allergens. Meanwhile, epidemiological studies have produced inconsistent findings regarding relationships between phthalate exposures and allergic disease in humans. The present study examined phthalate exposure and allergic sensitization in a large group of 3-5 year old children: 300 random controls and 200 cases with asthma, rhinoconjunctivitis or atopic dermatitis as reported in questionnaires. The children were clinically examined to confirm their health status. Blood samples were analyzed for IgE sensitization to 20 allergens. Adjusted logistic regressions were used to look for associations between phthalate exposure indicators (mass fractions in dust from children's homes and daycares, metabolites in urine, and estimated daily indoor intakes from dust ingestion, inhalation and dermal absorption) and sensitization and allergic disease. No direct associations were found between phthalate exposures and asthma, rhinoconjunctivitis or atopic dermatitis. However, among children with these diseases, there were significant associations between non-dietary exposures to DnBP, BBzP and DEHP in the indoor environment (mass fractions in dust or daily indoor intakes from dust ingestion, inhalation and dermal absorption) and allergic sensitization. Some exposure pathways were more strongly associated with sensitization than others, although the results are not conclusive and require confirmation. A number of the associations depended on accounting for a child's exposure in more than one environment (i.e., daycare facility as well as home). Significant associations were not observed between phthalate metabolites in urine, which reflected exposure from diet as well as indoor pathways, and allergic sensitization. (C) 2015 Elsevier Inc. All rights reserved.