FAMILIAL AND SPORADIC SCHIZOPHRENIA - A SIMULATION STUDY OF STATISTICAL POWER
FAMILIAL AND SPORADIC SCHIZOPHRENIA - A SIMULATION STUDY OF STATISTICAL POWER
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DOI：
10.1016/0920-9964(89)90026-1
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发表时间：
1989-07-01
影响因子：
4.5
通讯作者：
TSUANG, MT
中科院分区：
文献类型：
--
作者：
LYONS, MJ;FARAONE, SV;TSUANG, MT
遗传因素在精神分裂症中的重要性是清楚的，但涉及的机制仍然不清楚。病因异质性可能是原因。最近，人们对基于该疾病的阳性或阴性家族史的疾病的遗传和环境形式之间的假定区别感兴趣。那些有阳性家族史的人被归类为“家族性”，被认为更有可能患有这种疾病的遗传形式。那些有阴性家族史的人被归类为“散发性”，并被认为更有可能患有环境形式的疾病。本文报告了不同的错误分类率的Monte Carlo模拟研究的结果，以确定家庭和散发组之间的比较的统计能力。对于大样本（n=175），效应量大于或等于1.0标准差单位且阳性预测值为0.3或更高时，统计功效为中度至良好。
The importance of genetic factors in schizophrenia is clear but the mechanism involved remains obscure. Etiological heterogeneity may be responsible. Recently there has been interest in a putative distinction between genetic and environmental forms of the illness based on a positive or negative family history of the disorder. Those with a positive family history are classified as ‘familial’ and are considered to be more likely to have the genetic form of the illness. Those with a negative family history are classified as ‘sporadic’ and considered more likely to have an environmental form of the illness. This paper reports the results of a Monte Carlo simulation study with varying rates of misclassification to determine the statistical power of comparisons between familial and sporadic groups. For a large sample (n=175) statistical power was moderate to good for effect sizes greater than or equal to 1.0 standard deviation unit and positive predictive value of 0.3 or greater.