PROLIFERATING BIPOTENTIAL GLIAL PROGENITOR CELLS IN ADULT-RAT OPTIC-NERVE
PROLIFERATING BIPOTENTIAL GLIAL PROGENITOR CELLS IN ADULT-RAT OPTIC-NERVE
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DOI：
10.1038/319499a0
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发表时间：
1986-02-06
期刊：
影响因子：
64.8
通讯作者：
RAFF, MC
中科院分区：
文献类型：
--
作者：
FFRENCHCONSTANT, C;RAFF, MC
我们以前已经证明，大鼠视神经包含三种类型的大胶质细胞-少突胶质细胞和两种类型的星形胶质细胞-它们以两种不同的谱系发育。1型星形胶质细胞从胚胎第16天(E16)1开始发育成一种类型的前体细胞，而少突胶质细胞和2型星形胶质细胞分别从出生时(E21)和出生后7-10天(P7-10)发育成共同的、双潜能的前体细胞。在这里，我们报道在成年大鼠的视神经中存在增殖的双潜能少突胶质细胞-2型星形胶质细胞(0-2A)前体细胞，这增加了这些细胞在一生中不断从自我更新的干细胞中产生的可能性。
We have shown previously that the rat optic nerve contains three types of macroglial cells—oligodendrocytes and two types of astrocytes—which develop as two distinct lineages. Type-1 astrocytes develop from one type of precursor cell beginning at embryonic day 16 (E16)1, while oligodendrocytes and then type-2 astrocytes develop from a common, bipotential progenitor cell beginning at birth (E21) and postnatal days 7–10 (P7–10), respectively2. Here we report that proliferating bipotential oligoden-drocyte-type-2 astrocyte (0-2A) progenitor cells are present in the adult rat optic nerve, raising the possibility that these cells are produced continually from self-renewing stem cells throughout life.