RABBIT BONE COLLAGENASE INHIBITOR BLOCKS THE ACTIVITY OF OTHER NEUTRAL METALLOPROTEINASES
RABBIT BONE COLLAGENASE INHIBITOR BLOCKS THE ACTIVITY OF OTHER NEUTRAL METALLOPROTEINASES
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DOI：
10.1016/0006-291x(79)91834-5
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发表时间：
1979-01-01
影响因子：
3.1
通讯作者：
REYNOLDS, JJ
中科院分区：
文献类型：
--
作者：
SELLERS, A;MURPHY, G;REYNOLDS, JJ
兔骨外植体在培养的前几天产生胶原酶抑制剂，随后产生中性金属蛋白酶，胶原酶是其中之一。胶原酶抑制剂可能阻断了其他中性金属蛋白酶的活性(经4-氨基苯基汞醋酸酯激活后)，表明1抑制剂是参与结缔组织分解代谢的所有金属蛋白酶的单一调节因子。
Rabbit bone explants produced a collagenase inhibitor during the 1st few days in culture and later produced neutral metalloproteinases, one of which is collagenase. The collagenase inhibitor possibly blocked the activity of the other neutral metalloproteinases (after activation by 4-amino-phenylmercuric acetate), indicating that 1 inhibitor functions as a single regulator for all the metalloproteinases involved in connective tissue catabolism.