Mucosal wound healing - The roles of age and sex
Mucosal wound healing - The roles of age and sex
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DOI：
10.1001/archsurg.141.12.1193
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发表时间：
2006-12-01
影响因子：
--
通讯作者：
Marucha, Phillip T.
中科院分区：
文献类型：
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作者：
Engeland, Christopher G.;Bosch, Jos A.;Marucha, Phillip T.
假设：目前尚不清楚衰老是否会延迟伤口愈合，因为过去的人体研究没有充分控制诸如发病率和药物等混杂因素。此外，尽管女性皮肤伤口愈合速度比男性快，但临床观察表明，粘膜愈合的情况可能正好相反。我们评估了粘膜伤口愈合的年龄和性别差异，我们假设年龄延迟愈合和性别调节愈合与年龄无关。设计和设置：临床实验研究从2000年6月至2003年8月进行，涉及年轻和老年志愿者从一般社区。参与者：212名男性和女性志愿者，年龄在18至35岁（n = 119）或50至88岁（n = 93）。干预：在志愿者的口腔硬腭上放置标准化的3.5 mm圆形伤口。主要结果测量：结果：老年人伤口愈合明显慢于年轻人（P
Hypothesis: It remains unclear whether aging delays wound healing, as past human studies have not adequately controlled for confounding factors such as morbidity and medications. Furthermore, although dermal wounds heal more quickly in women than in men, clinical observations suggest that the opposite may be true for mucosal healing. We assessed age and sex differences in mucosal wound healing, and we hypothesized that aging delays healing and sex modulates healing independent of age.Design and Setting: Clinical experimental study performed from June 2000 to August 2003 involving younger and older adult volunteers from the general community.Participants: Two hundred twelve mate and female volunteers aged 18 to 35 years (n = 119) or 50 to 88 years (n = 93).Intervention: Standardized 3.5-mm circular wounds were placed on the oral hard palates of volunteers.Main Outcome Measure: Wound videographs were taken daily for 7 days after wounding to assess wound closure.Results: Wounds healed significantly more slowly in older adults compared with younger adults (P