A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum
A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum
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DOI：
10.1038/s41467-019-09145-6
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yanni Yin
中科院分区：
文献类型：
--
作者：
Zunyong Liu;Yunqing Jian;Yun Chen;Harold Kistler;Ping He;Zhongha Ma;Yanni Yin
Sterol biosynthesis is controlled by transcription factor SREBP in many eukaryotes. Here, we.show that SREBP orthologs are not involved in the regulation of sterol biosynthesis in.Fusarium graminearum, a fungal pathogen of cereal crops worldwide. Instead, sterol production.is controlled in this organism by a different transcription factor, FgSR, that forms a.homodimer and binds to a 16-bp cis-element of its target gene promoters containing two.conserved CGAA repeat sequences. FgSR is phosphorylated by the MAP kinase FgHog1, and.the phosphorylated FgSR interacts with the chromatin remodeling complex SWI/SNF at the.target genes, leading to enhanced transcription. Interestingly, FgSR orthologs exist only in.Sordariomycetes and Leotiomycetes fungi. Additionally, FgSR controls virulence mainly via.modulating deoxynivalenol biosynthesis and responses to phytoalexin.
