Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination
Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination
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DOI：
10.1007/s10147-014-0723-1
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发表时间：
2015-06-01
影响因子：
3.3
通讯作者：
Takagi, Tetsu
中科院分区：
文献类型：
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作者：
Morimoto, Akiko;Ueda, Yutaka;Takagi, Tetsu
在有关疫苗不良事件的广泛报道以及政府暂停推荐该疫苗后，日本的人乳头瘤病毒（HPV）疫苗接种量急剧减少。在这项研究中，我们调查了已接种疫苗的青少年对宫颈癌、癌症筛查和 HPV 疫苗的了解和接受程度。此外，我们还分析了该消息是否影响了疫苗接种的接受度以及影响程度。本研究是大阪 HPV 疫苗临床研究 (OCEAN) 研究的一部分。向 2,777 名研究登记者发放了一份调查问卷。回应率为 38%。疫苗不良事件新闻识别率80%；对于政府宣布暂停推荐疫苗的认知度为 68%。在接种期间有机会听到或看到负面消息的人中，46人（60%）在知道该消息的情况下继续接种，22人（29%）停止接种，9人（11%）在不知道该消息的情况下继续接种。有关疫苗不良事件的报告是不继续接种疫苗系列的主要原因。那些在听到不利消息后咨询医生的人比那些没有接种疫苗的人更有可能继续接种疫苗。我们的结果应该有助于理解在未来撤销建议暂停后大力促进疫苗使用和癌症筛查的必要性。这可能适用于由于担心疫苗不良事件而导致 HPV 疫苗接种率不理想的其他国家。
Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination.This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants.The response rate was 38 %. The recognition rate of the news of the vaccine's adverse events was 80 %; it was 68 % for awareness of the government's announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60 %) continued vaccination while knowing of the news, 22 (29 %) discontinued vaccination, and 9 (11 %) continued vaccination without an awareness of the news. Reports of the vaccine's adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not.Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.