Smaller volume and altered functional connectivity of the amygdala in patients with lifelong premature ejaculation
Smaller volume and altered functional connectivity of the amygdala in patients with lifelong premature ejaculation
复制标题
终生早泄患者杏仁核体积变小且功能连接改变
DOI：
10.1007/s00330-021-08002-9
复制
发表时间：
2021-04-30
影响因子：
5.9
通讯作者：
Liu, Peng
中科院分区：
文献类型：
--
作者：
Geng, Bowen;Gao, Ming;Liu, Peng
目的分析44例早泄（premature ejaculation，PE）患者和31例健康对照者杏仁核结构和功能的异常。使用早泄诊断工具（PEDT）和阴道内射精潜伏时间（IELT）评分诊断每位受试者患有PE。结果终身PE患者双侧杏仁核灰质体积减少，杏仁核与楔前叶、后扣带皮层之间的FC增加，与正常对照组比较，差异有显著性（P < 0. 05）。和中颞叶皮层（MTC），以及杏仁核和中央前回之间的FC减少，杏仁核和额下回。此外，IELT分数与杏仁核-MTC的平均z分数之间呈显著负相关，（r =-0.49）和杏仁核-PCC（r =-0.48）FC被发现在终身PE patient.ConclusionsOur研究调查异常杏仁核相关的结构和连接模式在PE患者，这可能为了解杏仁核在PE神经机制中的重要作用提供新的视角。要点·作为男性最常见的疾病之一，PE可能与异常的大脑机制有关。·功能和结构磁共振成像用于探索PE患者的杏仁核异常。通过临床评分与功能连接的相关性来评价结果的合理性。
ObjectivesTo analyze the abnormal amygdala structure and function in lifelong premature ejaculation (PE) patients compared with healthy controls (HCs).MethodsForty-four lifelong PE patients and thirty-one HCs were enrolled in this study. Each subject was diagnosed with PE using a Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculation latency time (IELT) score. Based on t-tests and Pearson correlation analysis, the voxel-based morphometry and functional connectivity (FC) analyses were applied to evaluate brain structural and functional changes by using T1-weighted and resting-state functional magnetic resonance imaging scans.ResultsLifelong PE patients had decreased gray matter volume in the bilateral amygdala and increased FC between the amygdala and precuneus, posterior cingulate cortex (PCC), and middle temporal cortex (MTC), as well as decreased FC between the amygdala and precentral gyrus, insula, and inferior frontal gyrus. Moreover, significantly negative correlations between the IELT score and the mean z-score from amygdala-MTC (r = −0.49) and amygdala-PCC (r = −0.48) FC were found in lifelong PE patients.ConclusionsOur study investigated the abnormal amygdala-related structure and connectivity patterns in PE patients, which might provide novel perspective for understanding the crucial role of the amygdala in the neural mechanism of PE.Key Points• As one of the most common diseases in men, PE may be related to abnormal brain mechanisms.• Functional and structural magnetic resonance imaging used to explore amygdala abnormalities in PE patients.• The correlation between clinical scores and functional connectivity was used to assess the reasonability of the results.