Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and the role of ethanol and radioactive concentration
Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and the role of ethanol and radioactive concentration
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DOI：
10.1016/j.apradiso.2009.01.005
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发表时间：
2009-06-01
影响因子：
1.6
通讯作者：
Mahoney, Douglas W.
中科院分区：
文献类型：
--
作者：
Jacobson, Mark S.;Dankwart, Heather R.;Mahoney, Douglas W.
放射分解是放射性标记化合物降解的过程。许多具有高放射性浓度和比活度的正电子发射断层扫描 (PET) 放射性药物由于放射分解而表现出较低的放射化学纯度。描述 2-[F-18]氟-2-脱氧-D-葡萄糖 ([F-18]FDG) 放射分解的数据很少。我们研究的目的是通过测量不同时间间隔的放射化学纯度来分析 [F-18]FDG 在不同放射性浓度下的降解情况，并研究乙醇（一种众所周知的 [F-18]FDG 制剂还原剂稳定剂）的影响。 (C) 2009 年，爱思唯尔有限公司出版。
Radiolysis is the process by which radioactively labeled compounds degrade. Many positron emission tomography (PET) radiopharmaceuticals produced with high radioactive concentrations and specific activities exhibit low radiochemical purity because of radiolysis. Little data exist that describe the radiolytic decomposition of 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG). The objective of our study was to profile the degradation of [F-18]FDG at various radioactive concentrations by measuring radiochemical purity at different time intervals and to study the effects of ethanol, a well-known reductant stabilizer of [F-18]FDG preparations. (C) 2009 Published by Elsevier Ltd.