Megalin-mediated endocytosis in renal proximal tubule
Megalin-mediated endocytosis in renal proximal tubule
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DOI：
10.3109/08860229809045102
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发表时间：
1998-01-01
期刊：
影响因子：
3
通讯作者：
Moestrup, SK
中科院分区：
文献类型：
--
作者：
Christensen, EI;Birn, H;Moestrup, SK
Megalin是一种属于IDL受体家族的600 kDa膜蛋白，在肾近端小管的内吞途径中高度表达。此外，这种受体在其他几种面向跨细胞液的上皮细胞中发现，但也在甲状旁腺中表达。最近的研究已经确定这种蛋白质可能是肾小球中过滤的大分子内吞作用的最重要的受体。据报道与巨蛋白结合的配体由多种不同的物质组成，包括白蛋白、维生素载体复合物、蛋白酶和蛋白酶抑制剂复合物、脂蛋白颗粒、受体相关蛋白（RAP）、不同的药物和钙。
Megalin a 600 kDa membrane protein belonging to the IDL receptor family is highly expressed in the endocytic pathway of renal proximal tubules. In addition, this receptor is found in several other epithelia facing transcellular fluids but is also expressed in the parathyroid glands. Recent studies have established this protein as probably the most important receptor for endocytosis of macromolecules filtered in the renal glomeruli. The ligands reported to bind to megalin consist of a variety of different substances including albumin, vitamin-carrier complexes, proteinases and proteinase-inhibitor complexes, lipoprotein particles, receptor associated protein (RAP), different drugs and calcium.