Cryptides: Functional cryptic peptides hidden in protein structures
Cryptides: Functional cryptic peptides hidden in protein structures
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DOI：
10.1002/bip.20687
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发表时间：
2007-01-01
期刊：
影响因子：
2.9
通讯作者：
Mukai, Hidehito
中科院分区：
文献类型：
--
作者：
Ueki, Nobuhiko;Someya, Kazuya;Mukai, Hidehito
肽能激素、神经递质和神经调节剂是细胞外信号分子，在各种细胞、组织和器官之间的生理信号传递中发挥核心作用。根据遗传信息，这些因子主要被翻译为非活性蛋白质。然后这些前体蛋白被各种蛋白酶（包括信号肽酶和加工酶）裂解，产生成熟的生物活性因子。在这些过程中，相同的前体蛋白也会产生各种片段肽。这样的片段化肽可能具有尚未被鉴定的各种意想不到的生物活性，因为这些肽被认为是与相同分泌途径中的成熟因子一起产生和释放的。最近，我们发现在成熟过程中产生的各种线粒体蛋白片段肽，例如细胞色素c氧化酶片段，可以激活中性粒细胞，其功能与其亲本蛋白不同。这些发现表明存在许多不同的功能肽，其功能尚未确定。这些未鉴定的肽可能在各种调控机制中发挥多种作用，因此，它们有望提供新的调控和信号传导机制“肽世界”。 (c) 2007 年 Wiley 期刊公司。生物聚合物（Pept Sci）88：190-198，2007 年。
Peptidergic hormones, neurotransmitters, and neuromodulators are extracellular signaling molecules that play central roles in physiological signal transmission between various cells tissues, and organs. These factors are primarily translated as inactive proteins according to the genetic information. These Precursor proteins are then cleaved by various proteases including signal peptidases and processing enzymes to produce matured bioactive factors. During these processes, various fragmented peptides are also produced from the same precursor proteins. Such, fragmented peptides may have various unexpected I biological activities that have not been identified yet because these peptides are considered to be produced and released along with mature factors at the same secretary pathways. Recently, we found that various fragmented peptides of mitochondrial proteins that are produced during the maturation processes, such as fragments of cytochrome c oxidase, activate neutrophils whose functions are distinct from their parent proteins. These findings suggest the existence of many different functional peptides whose functions have not been identified yet. These unidentified peptides may play a variety of roles in various regulatory mechanisms, therefore, they are expected to provide novel regulatory and signaling mechanisms, "Peptide World". (c) 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 190-198, 2007.