Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography
Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography
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DOI：
10.1117/1.jbo.18.11.111404
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发表时间：
2013-11-01
影响因子：
3.5
通讯作者：
Kang, Jin U.
中科院分区：
文献类型：
--
作者：
Huang, Yong;Ibrahim, Zuhaib;Kang, Jin U.
血管和微血管闭塞是重建显微外科、血管外科和移植外科的关键组成部分。使用提供深度视图和三维（3-D）成像的手术成像模式的术中手术引导可以潜在地改善传统和创新吻合技术的结果。当结合其他临床评估工具（如毛细血管再充盈、温度、皮肤变白和皮肤肿胀）时，闭塞血管的客观术后成像可能会提高挽救率。与其他当代术后监测模式（计算机断层扫描血管造影、磁共振（MR）血管造影和超声）相比，多普勒光学相干断层扫描（OCT）是一种无创高分辨率（微米级）、高速、3-D成像模式，已广泛应用于生物医学和临床应用。据我们所知，首次证明了实时三维相位分辨多普勒OCT（PRDOCT）作为啮齿动物股血管微血管吻合术的辅助术中和术后成像模式的可行性，这将为微血管和超微血管手术提供新的见解和潜在的突破。(C)2013年，美国光电仪器工程师学会（SPIE）
Vascular and microvascular anastomoses are critical components of reconstructive microsurgery, vascular surgery, and transplant surgery. Intraoperative surgical guidance using a surgical imaging modality that provides an in-depth view and three-dimensional (3-D) imaging can potentially improve outcome following both conventional and innovative anastomosis techniques. Objective postoperative imaging of the anastomosed vessel can potentially improve the salvage rate when combined with other clinical assessment tools, such as capillary refill, temperature, blanching, and skin turgor. Compared to other contemporary postoperative monitoring modalities- computed tomography angiograms, magnetic resonance (MR) angiograms, and ultrasound Doppler-optical coherence tomography (OCT) is a noninvasive high-resolution (micron-level), high-speed, 3-D imaging modality that has been adopted widely in biomedical and clinical applications. For the first time, to the best of our knowledge, the feasibility of real-time 3-D phase-resolved Doppler OCT (PRDOCT) as an assisted intra-and postoperative imaging modality for microvascular anastomosis of rodent femoral vessels is demonstrated, which will provide new insights and a potential breakthrough to microvascular and supermicrovascular surgery. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)