Mechanisms of acute cocaine toxicity.
Mechanisms of acute cocaine toxicity.
复制标题
DOI：
10.2174/1874143600802010070
复制
发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Zahniser, Nancy R
中科院分区：
文献类型：
--
作者：
Heard, Kennon;Palmer, Robert;Zahniser, Nancy R
急性可卡因中毒患者会出现危及生命的症状，涉及多个器官系统。虽然可卡因的作用是无数的，但它们是有限数量的可卡因-蛋白质相互作用的结果，包括单胺转运蛋白、神经递质受体和电压门控离子通道。这些主要的相互作用触发了一系列事件，最终产生临床效应。本文的目的是审查可卡因的主要相互作用和这些相互作用触发的影响。我们还描述了可卡因中毒症状的进展，因为它们与血清可卡因浓度有关。
Patients with acute cocaine poisoning present with life-threatening symptoms involving several organ systems. While the effects of cocaine are myriad, they are the result of a limited number of cocaine-protein interactions, including monoamine transporters, neurotransmitter receptors and voltage-gated ion channels. These primary interactions trigger a cascade of events that ultimately produce the clinical effects. The purpose of this article is to review the primary interactions of cocaine and the effects that these interactions trigger. We also describe the progression of symptoms observed in cocaine poisoning as they relate to serum cocaine concentrations.