Head and neck tumours: combined MRI assessment based on IVIM and TIC analyses for the differentiation of tumors of different histological types
Head and neck tumours: combined MRI assessment based on IVIM and TIC analyses for the differentiation of tumors of different histological types
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DOI：
10.1007/s00330-013-3002-z
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发表时间：
2014-01-01
影响因子：
5.9
通讯作者：
Nakamura, Takashi
中科院分区：
文献类型：
--
作者：
Sumi, Misa;Nakamura, Takashi
目的探讨体素内非相干运动（IVIM）和时间-信号强度曲线（TIC）分析在头颈部肿瘤诊断中的应用价值。方法对92例不同组织学类型的头颈部肿瘤进行IVIM理论和TIC曲线的灌注相关参数（PP）和分子扩散值（D）的比较。结果IVIM参数（PP）和TIC曲线（D）均与组织学类型有关。结论IVIM理论和TIC曲线（D）对头颈部肿瘤的诊断有重要价值在不同类型的头颈部肿瘤中，包括鳞状细胞癌（SCC）、淋巴瘤、恶性唾液腺肿瘤、沃辛瘤、多形性腺瘤和神经鞘瘤，组合的（f和D值）和TIC谱是不同的。结论IVIM参数和TIC参数联合应用对头颈部肿瘤的诊断有较高的准确性，其MR灌注/弥散特性广泛，动态增强（DCE）可用于头颈部肿瘤的MRI诊断，而MRI检查可用于头颈部肿瘤的MRI诊断。MR成像可以显示肿瘤的血流灌注（TIC分析），体素内非相干运动（IVIM）成像可以提供弥散和血流灌注特征，但单独的IVIM或DCE成像不足以诊断头颈部肿瘤，IVIM和TIC结合的多参数成像有助于诊断。
Objectives We evaluated the combined use of intravoxel incoherent motion (IVIM) and time-signal intensity curve (TIC) analyses to diagnose head and neck tumours.Methods We compared perfusion-related parameters (PP) and molecular diffusion values (D) determined from IVIM theory and TIC profiles among 92 tumours with different histologies.Results IVIM parameters (f and D values) and TIC profiles in combination were distinct among the different types of head and neck tumours, including squamous cell carcinomas (SCCs), lymphomas, malignant salivary gland tumours, Warthin's tumours, pleomorphic adenomas and schwannomas. A multiparametric approach using both IVIM parameters and TIC profiles differentiated between benign and malignant tumours with 97 % accuracy and diagnosed different tumour types with 89 % accuracy.Conclusions Combined use of IVIM parameters and TIC profiles has high efficacy in diagnosing head and neck tumours.Key pointsHead and neck tumours have wide MR perfusion/diffusion properties.Dynamic contrast-enhanced (DCE) MR imaging can characterise tumour perfusion (TIC analysis).Intravoxel incoherent motion (IVIM) imaging can provide diffusion and perfusion properties.However, IVIM or DCE imaging alone is insufficient for diagnosing head/neck tumours.Multiparametric approach using both IVIM and TIC profiles can facilitate the diagnosis.