High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects
High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects
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DOI：
10.1017/s0007114510003697
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发表时间：
2011-02-01
影响因子：
3.6
通讯作者：
Jones, Peter J. H.
中科院分区：
文献类型：
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作者：
Gillingham, Leah G.;Gustafson, Jennifer A.;Jones, Peter J. H.
最近，一种新型的脂肪酸修饰的膳食油被制造出来，以提高脂肪酸的摄入量，降低心血管疾病的风险。我们的目的是评估新型高油籽油（HOCO）单独使用或与亚麻籽油（FXCO）混合使用对典型西方饮食（WD）的循环脂质和炎症生物标志物的影响。采用一项随机、对照、交叉试验，36名高胆固醇血症受试者在28天内食用三种等能饮食，每种饮食含有约36%的脂肪能量，其中70%由HOCO、FXCO或WD提供。饲料中SFA、MUFA、PUFA n-6和n-3的脂肪含量分别为HOCO能量的6%、23%、5%和1%；6、16、5、7.5%的能量为FXCO；11.5、16、6、0.5%的能量用于WD。28 d后，与对照组相比，ldl -胆固醇降低15.1% (P
Recently, novel dietary oils with modified fatty acid profiles have been manufactured to improve fatty acid intakes and reduce CVD risk. Our objective was to evaluate the efficacy of novel high-oleic rapeseed (canola) oil (HOCO), alone or blended with flaxseed oil (FXCO), on circulating lipids and inflammatory biomarkers v. a typical Western diet (WD). Using a randomised, controlled, crossover trial, thirty-six hypercholesterolaemic subjects consumed three isoenergetic diets for 28 d each containing approximately 36% energy from fat, of which 70% was provided by HOCO, FXCO or WD. Dietary fat content of SFA, MUFA, PUFA n-6 and n-3 was 6, 23, 5, 1% energy for HOCO; 6, 16, 5, 7.5% energy for FXCO; 11.5, 16, 6, 0.5% energy for WD. After 28 d, compared with WD, LDL-cholesterol was reduced 15.1% (P