High levels of active quiescin Q6 sulfhydryl oxidase (QSOX) are selectively present in fetal serum
High levels of active quiescin Q6 sulfhydryl oxidase (QSOX) are selectively present in fetal serum
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DOI：
10.1179/135100005x83699
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发表时间：
2005-12
期刊：
影响因子：
3.8
通讯作者：
Silvio M. Zanata;A. C. Luvizon;D. F. Batista;C. M. Ikegami;Fábio O. Pedrosa;Evelise Machado de Souza;Daniela Fojo Seixas Chaves;Luiz Felipe Caron;J. V. Pelizzari;Francisco R.M. Laurindo;Lia S. Nakao
中科院分区：
文献类型：
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作者：
Silvio M. Zanata;A. C. Luvizon;D. F. Batista;C. M. Ikegami;Fábio O. Pedrosa;Evelise Machado de Souza;Daniela Fojo Seixas Chaves;Luiz Felipe Caron;J. V. Pelizzari;Francisco R.M. Laurindo;Lia S. Nakao
摘要硫氧还蛋白等硫醇氧化还原酶在着床、胚胎发生和胎儿发育中的作用已被广泛研究。在这里，我们分析了硫氧还蛋白超家族酶静止素Q6/巯基氧化酶(QSOX)在发育过程中的表达。结果表明，胎牛血清(孕4个月)中存在QSOX，但其水平在出生后(从出生后1~60天)呈下降趋势。我们还证明，在这类血清中，巯基氧化酶的活性与QSOX的表达相关，这表明在发育程序的氧化还原调节中可能起到了作用。
Abstract The participation of thiol-oxidoreductases such as thioredoxin during implantation, embryogenesis and fetal development has been extensively studied. Here, we analyzed the expression of the thioredoxin superfamily enzyme quiescin Q6/sulfhydryl oxidase (QSOX) during development. Results show that QSOX is present in fetal bovine serum (4 months' gestation), but its levels decrease with time after birth (from P1 to P60). We also demonstrate that a sulfhydryl oxidase activity correlates with QSOX expression in such sera, suggesting a putative role in the redox modulation of developmental programs.