Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data.
Differences between carcinoma of the cecum and ascending colon: Evidence based on clinical and embryological data.
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盲肠癌和升结肠癌之间的差异：基于临床和胚胎学数据的证据
DOI：
10.3892/ijo.2018.4366
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发表时间：
2018-07
影响因子：
5.2
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Xie X;Zhou Z;Song Y;Wang W;Dang C;Zhang H
盲肠在5周龄的胚胎中由盲肠憩室迅速发育而成，盲肠由中肠袢的尾段发育而成，与升结肠不同。本研究的目的是分析盲肠癌和升结肠癌患者的不同临床病理学和生物学特征。我们从监测、流行病学和最终结果数据库中获取了59，035例盲肠和升结肠腺癌患者的数据，以探讨临床病理特征与总生存率之间的潜在相关性。此外，我们分析了基因表达综合数据库中两个片段之间的基因表达差异。结果在癌症基因组图谱数据库中进行了验证，以及与西安交通大学第一附属医院的另一个独立数据集进行了验证。本研究的结果揭示了盲肠腺癌和升结肠腺癌之间潜在的预后差异，这可能是由SLCO 1B3基因的差异表达水平引起的。当包括SLCO 1B3在术中检查的淋巴结中的表达水平时，发现8个因素能够预测盲肠和升结肠癌患者的预后。在外科治疗策略上，切除>15个局部淋巴结有利于改善患者预后。
Developing rapidly from the cecal diverticulum in a 5-week-old embryo, the cecum, which is developed from the caudal limb of the midgut loop, is different from the ascending colon. The aim of this study was to analyze the different clinicopathological and biological characteristics of patients with carcinoma of the cecum and ascending colon. We accessed data for 59,035 patients with adenocarcinomas of the cecum and ascending colon from the Surveillance, Epidemiology and End Results database to explore the potential associations between the clinicopathological characteristics and overall survival. Furthermore, we analyzed the differences in gene expression between the two segments in the Gene Expression Omnibus database. The results were validated in The Cancer Genome Atlas database, as well as with another independent dataset from the First Affiliated Hospital of Xi'an Jiaotong University. The results of this study revealed the potential prognostic differences between adenocarcinoma of the cecum and ascending colon, which may be caused by the differential expression levels of the SLCO1B3 gene. When including the expression levels of SLCO1B3 in intraoperatively examined lymph nodes, 8 factors were found able to predict the prognosis of patients with carcinomas of the cecum and ascending colon. As regards the surgical therapeutic strategies, the resection of >15 local lymph nodes is appropriate for improving the prognosis of patients.
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DOI：
10.1016/s0749-0739(17)30241-9
发表时间：
1997-08-01
影响因子：
1.1
作者：
Dabareiner, RM;White, NA
通讯作者：
White, NA
影响因子：
4.8
作者：
König, J;Cui, YH;Keppler, D
通讯作者：
Keppler, D
影响因子：
45.3
作者：
O'Connor, Erin S.;Greenblatt, David Yu;Smith, Maureen A.
通讯作者：
Smith, Maureen A.
原发肿瘤位置作为转移性结直肠癌患者一线贝伐珠单抗疗效的预测因素。
影响因子：
3.9
作者：
He WZ;Liao FX;Jiang C;Kong PF;Yin CX;Yang Q;Qiu HJ;Zhang B;Xia LP
通讯作者：
Xia LP
影响因子：
3.8
作者：
Benedix, F.;Schmidt, U.;Kube, R.
通讯作者：
Kube, R.