Effect of arterial stretch on transmural albumin and Evan's blue dye transport.
Effect of arterial stretch on transmural albumin and Evan's blue dye transport.
复制标题
动脉拉伸对透壁白蛋白和埃文蓝染料转运的影响。
作者：
D. L. Fry;R. Mahley;S. Y. Oh
在犬胸降主动脉（DTA）内膜-内侧预备中，研究了动脉壁周向拉伸（lambda）对损伤内皮表面12i -白蛋白和埃文蓝染料（EBD） 32 min弥漫性壁摄取的影响。白蛋白摄取（MA nmol/cm2）采用标准伽马计数技术测量，EBD摄取（ME）采用反射法测量。在沿DTA的四个均匀位置(z)测量生理拉伸（lambda = 1.4）和高血压拉伸（lambda = 1.8）时的MA和ME。当λ从1.4变化到1.8时，MA的平均变化百分比为-2%，ME的平均变化百分比为-4%。这些降低并不显著（P大于0.10），我们得出结论，动脉壁拉伸对控制去内皮化动脉内膜-内侧组织系统内膜表面白蛋白和ebd白蛋白积累的参数只有很小的影响。
The influence of arterial wall circumferential stretch (lambda) on the 32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD) across the injured endothelial surface was studied in the intimal-medial preparation of the canine descending thoracic aorta (DTA). Albumin uptake (MA nmol/cm2) was measured by standard gamma counting techniques and the corresponding EBD uptake (ME) by the reflectance method. MA and ME were measured at a physiological stretch (lambda = 1.4) and at a hypertensive stretch (lambda = 1.8) at four equispaced locations (z) along the DTA. When lambda was changed from 1.4 to 1.8, the average percentage change of MA was -2% and of ME was -4%. These decreases were not significant (P greater than 0.10), and we conclude that arterial wall stretch exerts only minor influence on the parameters governing albumin and EBD-albumin accumulation in the intimal surface of the deendothelialized arterial intimal-medial tissue system.