Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum‐Schild equations
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum‐Schild equations
复制标题
新皮质切片中的氨基酸药理学：Hill 和 Gaddum-Schild 方程扩展的双分子作用证据
DOI：
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发表时间：
1988
影响因子：
7.3
通讯作者：
T. Stone
中科院分区：
文献类型：
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作者：
T. Williams;D.A.S. Smith;N. Burton;T. Stone
对皮质片制备的等效电路进行了分析，表明测量的直流电压可以用来估计作用于锥体细胞体的配体的希尔系数。2激动剂-拮抗剂相互作用的Gaddum - Schild方程已被修改，用于希尔系数不等于1的应用。所得方程已应用于Burton等人（1988）的最新数据。这些结果为N -甲基- D -天冬氨酸（NMDA）和喹啉酸激动剂以及犬尿酸和2 -氨基- 5 -磷酸-戊酸拮抗剂对小鼠新皮质锥体细胞NMDA受体的双分子作用提供了证据。
1 The equivalent circuit of the cortical slice preparation has been analysed to show that the measured d.c. voltages can be used to estimate the Hill coefficient for ligands acting on the pyramidal cell bodies. 2 The Gaddum‐Schild equation for agonist‐antagonist interactions has been modified for applications in which the Hill coefficient is not equal to 1. 3 The equations obtained have been applied to recent data of Burton et al. (1988). The results provide evidence for a bimolecular action of the agonists N‐methyl‐D‐aspartate (NMDA) and quinolinic acid and the antagonists kynurenic acid and 2‐amino‐5‐phosphono‐pentanoic acid at NMDA receptors on mouse neocortical pyramidal cells.