Inkjet-Printed Flexible Gold Electrode Arrays for Bioelectronic Interfaces
Inkjet-Printed Flexible Gold Electrode Arrays for Bioelectronic Interfaces
复制标题
DOI：
10.1002/adfm.201503316
复制
发表时间：
2016-02-16
影响因子：
19
通讯作者：
Arias, Ana C.
中科院分区：
文献类型：
--
作者：
Khan, Yasser;Pavinatto, Felippe J.;Arias, Ana C.
生物电子接口需要机械柔性和化学惰性的电极。柔性允许原始电极接触皮肤和组织，化学惰性防止电极与生物液体和活组织反应。因此，柔性金电极是生物阻抗和生物电位测量的理想选择，例如生物阻抗断层扫描、心电图（ECG）、脑电图（EEG）和肌电图（EMG）。然而，在塑料基板上制造金电极阵列的制造工艺仍然是难以捉摸的。在这项工作中，一个制造和低温烧结（类似于200摄氏度）技术被证明制造金电极。在低温烧结条件下，不同宽度的线表现出不同的烧结速度。因此，烧结条件以设计布局中最宽的特征为目标。制造的电极显示出62 μ m的最小特征尺寸和5 × 10（6）S m（-1）的电导率值。利用印刷和塑料电子工艺的多功能性，由31个电极组成的电极阵列，电极间距为2至7 mm，并用于在15 kHz下的共形表面的阻抗映射。总体而言，喷墨印刷的金电极阵列，是电气可重复的，机械稳健，并有前途的生物阻抗和生物电位测量的制造过程中证明。
Bioelectronic interfaces require electrodes that are mechanically flexible and chemically inert. Flexibility allows pristine electrode contact to skin and tissue, and chemical inertness prevents electrodes from reacting with biological fluids and living tissues. Therefore, flexible gold electrodes are ideal for bioimpedance and biopotential measurements such as bioimpedance tomography, electrocardiography (ECG), electroencephalography (EEG), and electromyography (EMG). However, a manufacturing process to fabricate gold electrode arrays on plastic substrates is still elusive. In this work, a fabrication and low-temperature sintering (similar to 200 degrees C) technique is demonstrated to fabricate gold electrodes. At low-temperature sintering conditions, lines of different widths demonstrate different sintering speeds. Therefore, the sintering condition is targeted toward the widest feature in the design layout. Manufactured electrodes show minimum feature size of 62 mu m and conductivity values of 5 x 10(6) S m(-1). Utilizing the versatility of printing and plastic electronic processes, electrode arrays consisting of 31 electrodes with electrode-to-electrode spacing ranging from 2 to 7 mm are fabricated and used for impedance mapping of conformal surfaces at 15 kHz. Overall, the fabrication process of an inkjet-printed gold electrode array that is electrically reproducible, mechanically robust, and promising for bioimpedance and biopotential measurements is demonstrated.