Pro54DB: a database for experimentally verified sigma-54 promoters
Pro54DB: a database for experimentally verified sigma-54 promoters
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DOI：
10.1093/bioinformatics/btw630
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发表时间：
2017-02-01
期刊：
影响因子：
5.8
通讯作者：
Lin, Hao
中科院分区：
文献类型：
--
作者：
Liang, Zhi-Yong;Lai, Hong-Yan;Lin, Hao
在原核生物中，sigma（54）启动子是一种独特的调控元件，由于其负责碳、氮相关基因的转录，并参与许多辅助过程和环境响应，因此受到广泛关注。对sigma（54）启动子的研究有助于更好地理解其在基因转录中的调控机制，并有助于准确发现被湿实验证据遗漏的基因。为了提供一个最新的、交互式的、可扩展的sigma（54）启动子数据库，建立了一个免费的、易于访问的sigma（54）启动子数据库Pro54DB（sigma（54）promoter database）。目前，该数据库已存储了从133篇文献中手工提取的43个物种的210个实验证实的sigma（54）启动子和297个调控基因，为生物信息学和分子生物学领域的研究人员提供了帮助。
In prokaryotes, the sigma(54) promoters are unique regulatory elements and have attracted much attention because they are in charge of the transcription of carbon and nitrogen-related genes and participate in numerous ancillary processes and environmental responses. All findings on sigma(54) promoters are favorable for a better understanding of their regulatory mechanisms in gene transcription and an accurate discovery of genes missed by the wet experimental evidences. In order to provide an up-to-date, interactive and extensible database for sigma(54) promoter, a free and easy accessed database called Pro54DB (sigma(54) promoter database) was built to collect information of sigma(54) promoter. In the current version, it has stored 210 experimental-confirmed sigma(54) promoters with 297 regulated genes in 43 species manually extracted from 133 publications, which is helpful for researchers in fields of bioinformatics and molecular biology.