Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners
Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners
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DOI：
10.1016/s0893-133x(98)00056-6
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发表时间：
1999-02-01
影响因子：
7.6
通讯作者：
Rüther, E
中科院分区：
文献类型：
--
作者：
Broocks, A;Meyer, T;Rüther, E
一些临床研究表明，有规律的有氧运动具有抗抑郁和抗焦虑的作用。为了研究运动对中枢血清素能受体敏感性的影响，我们对12名马拉松运动员和12名不经常锻炼的健康对照进行了神经内分泌挑战，分别使用口服剂量的间氯苯哌嗪（m-CPP, 0.4 mg/kg）、伊沙匹龙（0.3 mg/kg）和安慰剂。非选择性5-羟色胺能激动剂m-CPP主要通过其对5-HT2C受体的作用产生许多可重复的效果，在给予m-CPP后，马拉松运动员的皮质醇反应明显低于对照组。在运动员组中，m-CPP后催乳素反应也有统计学趋势。相比之下，两组在给予5-HT1A激动剂ipsapirone后观察到的皮质醇升高和低温程度相同。对nz-CPP或ipsapirone的行为反应以及血浆肾上腺素和去甲肾上腺素的平均最大升高在马拉松组和对照组之间没有差异。综上所述，运动诱导的5-HT2C受体下调可能在运动抗焦虑和抗抑郁作用中起重要作用。[j]中华医学会精神病学分会。Elsevier Science Inc.出版。
Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. To study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP, 0.4 mg/kg), ipsapirone (0.3 mg/kg) and placebo in 12 marathon runners and 12 healthy controls not practicing regular exercise. After administration of the nonselective serotonergic agonist m-CPP, which exerts a number of well-reproducible effects mainly by means of its action of 5-HT2C receptors, marathon runners showed a significantly reduced cortisol response in comparison to the control group. There was also a statistical trend toward a blunted prolactin response after m-CPP in the athlete group. In contrast, the increase of cortisol and the hypothermia observed after administration of the 5-HT1A agonist ipsapirone were of the same magnitude in both groups. The behavioral response to nz-CPP or ipsapirone and the mean maximal increases of plasma adrenaline and noradrenaline did not differ between the marathon and the control group. In conclusion, exercise-induced downregulation of 5-HT2C receptors could play an important role in mediating the anxiolytic and antidepressive effects of exercise. [Neuropsychopharmacology 20:150-162, 1999] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.