Behind the scenes: Are latent memories supported by calcium independent plasticity?
Behind the scenes: Are latent memories supported by calcium independent plasticity?
复制标题
DOI：
10.1002/hipo.23332
复制
发表时间：
2022-03
期刊：
影响因子：
3.5
通讯作者：
Dumas TC
中科院分区：
文献类型：
--
作者：
Keith RE;Ogoe RH;Dumas TC
N-甲基-D-天冬氨酸受体（NMDAR）由于其在神经元形态和突触传递的活性依赖性修饰中的中心作用，可以被认为是脑中事实上的“可塑性”受体。自20世纪80年代以来，对NMDAR的研究一直集中在钙的第二信使特性和介导神经形式和功能改变的下游信号通路上。最近，NMDAR被证明可以在没有钙离子内流的情况下驱动活动依赖性突触可塑性。这种“非离子型”可塑性如何在体外发生变得越来越清楚，但关于其参与行为和认知的研究还处于起步阶段。下游信号分子参与离子型和非离子型NMDAR依赖性可塑性，存在部分重叠。考虑到这一点，以及先前对离子型NMDAR可塑性的认知影响的研究，可以建立解释NMDAR非离子型可塑性如何影响学习和记忆的初步模型。我们推测，非离子型NMDAR可塑性参与了未成熟啮齿动物的潜在记忆编码，通过非关联性抑制突触的功效，并可能收缩树突棘。此外，海马中NMDAR组成的出生后晚期改变似乎减少了非离子型信号传导，并消除了对记忆提取的限制。这个框架大大改变了NMDAR参与空间认知和海马成熟的经典模型，并为未来的研究提供了新的和令人兴奋的进展。
N-methyl-D-aspartate receptors (NMDARs) can be considered to be the de facto “plasticity” receptors in the brain due to their central role in the activity-dependent modification of neuronal morphology and synaptic transmission. Since the 1980s, research on NMDARs has focused on the second messenger properties of calcium and the downstream signaling pathways that mediate alterations in neural form and function. Recently, NMDARs were shown to drive activity-dependent synaptic plasticity without calcium influx. How this “nonionotropic” plasticity occurs in vitro is becoming clearer, but research on its involvement in behavior and cognition is in its infancy. There is a partial overlap in the downstream signaling molecules that are involved in ionotropic and nonionotropic NMDAR-dependent plasticity. Given this, and prior studies of the cognitive impacts of ionotropic NMDAR plasticity, a preliminary model explaining how NMDAR nonionotropic plasticity affects learning and memory can be established. We hypothesize that nonionotropic NMDAR plasticity takes part in latent memory encoding in immature rodents through nonassociative depression of synaptic efficacy, and possibly shrinking of dendritic spines. Further, the late postnatal alteration in NMDAR composition in the hippocampus appears to reduce nonionotropic signaling and remove a restriction on memory retrieval. This framework substantially alters the canonical model of NMDAR involvement in spatial cognition and hippocampal maturation and provides novel and exciting inroads for future studies.
登录
查看更多内容
影响因子：
4.6
作者：
Addis L;Virdee JK;Vidler LR;Collier DA;Pal DK;Ursu D
通讯作者：
Ursu D
影响因子：
5.5
作者：
Bagley, Elena E.;Westbrook, Gary L.
通讯作者：
Westbrook, Gary L.
影响因子：
16.2
作者：
Barria, A;Malinow, R
通讯作者：
Malinow, R
DOI：
10.1073/pnas.1520029112
发表时间：
2015-11-24
影响因子：
11.1
作者：
Aow, Jonathan;Dore, Kim;Malinow, Roberto
通讯作者：
Malinow, Roberto
影响因子：
64.5
作者：
BOURTCHULADZE, R;FRENGUELLI, B;SILVA, AJ
通讯作者：
SILVA, AJ