Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits
Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits
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DOI：
10.1006/geno.2000.6435
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发表时间：
2001-02-15
期刊：
影响因子：
4.4
通讯作者：
Cookson, WOCM
中科院分区：
文献类型：
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作者：
Walley, AJ;Wiltshire, S;Cookson, WOCM
染色体5q31-q33细胞因子簇的多态标记与特应性和哮喘相关表型的连锁和关联已被许多研究小组报道。为了研究这一区域，29个多态标记被用来对233个家系组合进行基因分型。这些标记是根据遗传数据进行排序的，并辅之以已公布的遗传和物理图谱。哮喘(最显著的标志物IRF1，P=0.0002)和特应性疾病(CD14SNP，P=0.0001)存在显著的两点连锁。D5S463等位基因与特应性(P=0.002)和皮肤点刺试验指数(P=0.04)相关。这些数据支持在5q31-q33区域存在三个哮喘/特应性基因座的可能性，每个基因座的影响都相对较小。(C)2001年学术出版社。
Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a number of groups. To investigate this region, 29 polymorphic markers were used to genotype a combined set of 233 families. These markers were ordered based upon the genetic data, supplemented by published genetic and physical maps. Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect. (C) 2001 Academic Press.