Feasibility of exercise during treatment for multiple myeloma
Feasibility of exercise during treatment for multiple myeloma
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DOI：
10.1097/00002820-200310000-00012
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发表时间：
2003-10-01
期刊：
影响因子：
2.6
通讯作者：
Stewart, B
中科院分区：
文献类型：
--
作者：
Coleman, EA;Coon, S;Stewart, B
疲劳和失眠是癌症患者面临的问题。研究结果表明，有氧运动可以减少与癌症相关的疲劳。由于患有骨骼肌萎缩的癌症患者可能无法从有氧运动训练中获得最大益处，因此运动计划可能需要包括阻力训练。到目前为止，测试运动作为疲劳干预措施的重点是乳腺癌患者，排除了骨转移患者。有必要测试运动对于患有其他类型癌症和骨骼受累的患者的可行性和有效性。有氧运动和力量抗阻训练对癌症患者睡眠的影响尚未得到测试。进行了一项随机对照设计的试点/可行性研究，旨在调查 24 名接受大剂量化疗和自体外周血干细胞移植治疗多发性骨髓瘤的患者的家庭运动疗法。没有患者受伤。由于可行性研究中的样本量较小，运动对去脂体重的影响是唯一获得统计显着性的终点。然而，结果表明，对于接受积极治疗的多发性骨髓瘤患者来说，个性化的锻炼计划是可行的，并且可能有效减少疲劳和情绪障碍，并改善睡眠。
Fatigue and insomnia are problems for patients with cancer. Research findings show that aerobic exercise decreases cancer-related fatigue. Because patients with cancer who have skeletal muscle wasting may not obtain maximum benefit from aerobic exercise training, exercise programs may need to include resistance training. Thus far, testing exercise as an intervention for fatigue has focused on patients with breast cancer and excluded patients with bone metastasis. There is a need to test the feasibility and effectiveness of exercise for patients with other types of cancer and with bone involvement. The effect of aerobic and strength resistance training on the sleep of patients with cancer has not been tested. A pilot/feasibility study with a randomized controlled design was conducted to investigate home-based exercise therapy for 24 patients receiving high-dose chemotherapy and autologous peripheral blood stem cell transplantation as treatment for multiple myeloma. None of the patients injured themselves. Because of the small sample size in the feasibility study, the effect of exercise on lean body weight was the only end point that obtained statistical significance. However, the results suggest that an individualized exercise program for patients receiving aggressive treatment for multiple myeloma is feasible and may be effective for decreasing fatigue and mood disturbance, and for improving sleep.