Airway blood flow distribution and lung edema after histamine infusion in awake sheep.
Airway blood flow distribution and lung edema after histamine infusion in awake sheep.
复制标题
清醒羊输注组胺后气道血流分布和肺水肿。
DOI：
10.1152/jappl.1988.65.4.1847
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Cross,CE
中科院分区：
文献类型：
--
作者：
Kramer,GC;Lindsey,DC;Wu,CH;Mertens,S;Russell,LA;Cross,CE
本研究旨在评估未麻醉绵羊输注 2 小时组胺（2 微克.kg-1.min-1）期间支气管血流到主要气道和外周肺的分布情况，并对肺水肿进行定量。通过使用放射性微球，确定流向气管和气管软骨、平滑肌和粘膜/粘膜下层的血流，同时测量流向不同大小气道段的血流和流向肺实质的全身血流。组胺大大增加了中等大小（直径 5 至 10 毫米）中央气道的血流量，其中血流量增加了基线的 5-10 倍，而在小（直径 1 至 5 毫米）中央气道中，血流量增加了 10-15 倍。气管粘膜/粘膜下层的血流量增加了基线的六倍，但气管平滑肌的血流量仅增加了基线的三倍，而软骨中的血流量仍保持在基线。流向肺部的大部分全身血流灌注直径小于 1 毫米的外周气道，并且这些气道在组胺输注期间表现出较少的血管舒张。在组胺输注期间，流向全肺实质（全肺减去气管）的平均血流量仅为基线的两倍。组胺后气管和主干支气管含水量显着增加。组胺输注后的组织病理学结果包括气道充血和水肿，仅对肺泡产生轻微影响。我们得出的结论是，组胺是一种有效的、选择性的支气管血管扩张剂，尤其影响流向中央气道和气道粘膜/粘膜下层的血流。（摘要截断为 250 字）
The present study was designed to evaluate the distribution of bronchial blood flow to major airways and peripheral lung and to quantitate lung edema during a 2-h histamine infusion (2 micrograms.kg-1.min-1) in unanesthetized sheep. By the use of radioactive microspheres, the blood flow to trachea and to tracheal cartilage, smooth muscle, and mucosa/submucosa was determined along with measurements of blood flow to different sized airway segments and the systemic blood flow to lung parenchyma. Histamine greatly increased blood flow to medium-sized (5- to 10-mm-diam) central airways in which blood flow increased 5-10 times base line, whereas in small (1- to 5-mm-diam) central airways the increase was 10-15 times. Blood flow in tracheal mucosa/submucosa increased six times base line, but in tracheal smooth muscle the increase was only three times base line, and in cartilage it remained at base line. Most of the systemic blood flow to the lung perfuses less than 1-mm-diam peripheral airways, and these airways demonstrated less vasodilation during histamine infusion. Mean blood flow to whole-lung parenchyma (whole lung minus trachea) was only two times base line during histamine infusion. Water content of trachea and main stem bronchi was significantly increased after histamine. Histopathologic findings after histamine infusions included congestion and edema of airways with only minor effects noted in alveoli. We conclude that histamine is a potent and selective vasodilator of bronchial vessels and particularly affects blood flow to central airways and to airway mucosal/submucosa.(ABSTRACT TRUNCATED AT 250 WORDS)