Normal serotonin but elevated 5-hydroxyindoleacetic acid concentration in cerebellar cortex of patients with dominantly-inherited olivopontocerebellar atrophy.
Normal serotonin but elevated 5-hydroxyindoleacetic acid concentration in cerebellar cortex of patients with dominantly-inherited olivopontocerebellar atrophy.
复制标题
显性遗传性橄榄脑桥小脑萎缩患者的小脑皮质中血清素正常，但 5-羟基吲哚乙酸浓度升高。
DOI：
10.1016/0304-3940(92)90721-i
复制
发表时间：
1992
影响因子：
2.5
通讯作者：
Shannak,K
中科院分区：
文献类型：
--
作者：
Kish,SJ;Robitaille,Y;Schut,L;el-Awar,M;Ball,MJ;Shannak,K
Beas-Zarate and coworkers (Eur. J. Pharmacol., 198 (1991) 7–14) recently reported markedly reduced concentration of presynaptic serotonin neurotransmitter markers in cerebellum of rodents which had suffered destruction of the inferior olivary-cerebellar (climbing fibre) projections by the neurotoxin 3-acetylpyridine; these experimental animal data suggested that serotonin might be one of the neurotransmitters released by climbing fibres. We measured the concentration of serotonin and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) in autopsied cerebellar cortex of 14 patients with dominantly-inherited olivopontocerebellar atrophy (OPCA) who all had near-total degeneration of the inferior olivary climbing fibres. As compared with the controls, mean concentration of serotonin in cerebellar cortex of the OPCA patients was normal whereas 5-HIAA levels (+79%,P<0.02) and ‘turnover’ ratio 5-HIAA/serotonin (+148%,P<0.05), on average, were significantlyelevated. These data do not support the notion that serotonin is a predominant neurotransmitter of the human climbing fibre. However, the markedly elevated serotonin turnover ratio suggests the possibility of increased serotonergic neuronal activity, which might alter, and perhaps improve, the functioning of the preserved cerebellar cortical neurones in OPCA.
