Evaluation of medicinal plants from Mali for their in vitro and in vivo trypanocidal activity
Evaluation of medicinal plants from Mali for their in vitro and in vivo trypanocidal activity
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DOI：
10.1016/j.jep.2005.08.023
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发表时间：
2006-02-20
影响因子：
5.4
通讯作者：
Clausen, PH
中科院分区：
文献类型：
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作者：
Bizimana, N;Tietjen, U;Clausen, PH
研究了40种马里药用植物不同部位的水、甲醇和二氯甲烷提取物对布氏锥虫的杀锥虫活性。在低接种长时间孵育试验(LILIT)的165种提取物中，有24种提取物显示出较高的杀锥虫活性。用长期存活试验(Ltd VA)对24个提取物的结果进行验证，发现15个样品的最低抑菌浓度(MIC)为10mU g/ml，8个样品的MIC值为100 mU g/ml，1个样品的MIC值为50~100 mU g/ml，迄今已有4个样品的MIC值为50~100 mU g/ml
Water, methanol and dichloromethane extracts prepared from various parts of 40 medicinal plant species from Mali were investigated for their trypanocidal activity against Trypanosoma brucei brucei. Of a total of 165 extracts tested in vitro in the Low Inoculation Long Incubation Test (LILIT) 24 extracts showed a high trypanocidal activity. Using the Long-Term Viability Assay (LtVA) for corroboration of the results of the 24 extracts, it was found that 15 samples had minimum inhibitory concentration (MIC) values > 10 mu g/ml, eight MIC values of 100 mu g/ml and one MIC values of 50-100 mu g/ml. So far, four extracts with MIC values